AiPD: Autoinhibited Protein Database

Q8IZ69

Gene name	TRMT2A
Protein name	tRNA (uracil-5-)-methyltransferase homolog A
Names	mRNA (uracil-5-)-methyltransferase TRMT2A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27037
EC number	2.1.1.35: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

562-625 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

562-625 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q8IZ69

Entry ID	Method	Resolution	Chain	Position	Source
7NTN	X-ray	202 A	A	69-147	PDB
7NTO	X-ray	123 A	A	69-147	PDB
AF-Q8IZ69-F1	Predicted				AlphaFoldDB

187 variants for Q8IZ69

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1209800510	6	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	9	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	49	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374854124	82	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1242151140	85	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200653246	128	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs760703455	132	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs189442480	142	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	150	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777596749	156	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	169	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	172	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746476053	182	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs201499233	186	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs752219491	192	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs879377585	221	N>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1568973506	221	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA10107891 rs780450166	233	S>*		No	ClinGen ExAC gnomAD
CA10107889 rs746180847	236	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs781727703 CA10107888	236	Q>H		No	ClinGen ExAC gnomAD
rs1160678332 CA410720368	237	T>I		No	ClinGen TOPMed
rs1378318102 CA410720360	238	E>D		No	ClinGen TOPMed
rs200273141 CA10107850	240	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA10107849 rs566798710	240	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1343770140 CA410720346	241	N>H		No	ClinGen gnomAD
rs547249953 CA10107848	241	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10107847 rs547249953	241	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA322183410 rs754700959	243	C>G		No	ClinGen ExAC
CA10107845 rs754700959	243	C>R		No	ClinGen ExAC
CA410720332 rs1346362141	243	C>Y		No	ClinGen gnomAD
rs1335801080 CA410720321	244	E>D		No	ClinGen TOPMed
CA410720318 rs1277089544	245	F>L		No	ClinGen TOPMed gnomAD
rs370644731 CA322183402	246	L>P		No	ClinGen ESP TOPMed gnomAD
rs986438485 CA322183405	246	L>V		No	ClinGen gnomAD
TCGA novel	247	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779712851 CA10107843	248	G>A		No	ClinGen ExAC gnomAD
rs530359242 CA10107841	249	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761732799 CA10107839	250	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs765205634 CA10107837	251	V>M		No	ClinGen ExAC TOPMed gnomAD
CA410720276 rs1266850891	252	D>E		No	ClinGen TOPMed
CA10107836 rs759610393	255	D>G		No	ClinGen ExAC gnomAD
rs778212012 CA322183323	255	D>N		No	ClinGen Ensembl
rs776749209 CA10107835	257	T>S		No	ClinGen ExAC TOPMed gnomAD
CA10107834 rs771209360	258	V>M		No	ClinGen ExAC TOPMed gnomAD
CA322183305 rs950456663	260	C>S		No	ClinGen TOPMed gnomAD
rs1026113720 CA322183301	261	R>W		No	ClinGen TOPMed gnomAD
rs376077653 CA10107832	263	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs376077653 CA322183297	263	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10107831 rs372333903	266	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA10107830 rs748635335	266	K>R		No	ClinGen ExAC TOPMed gnomAD
CA10107827 rs748795551	268	G>A		No	ClinGen ExAC gnomAD
CA10107828 COSM1032192 rs768076994	268	G>R	endometrium Variant assessed as Somatic; 4.637e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs779580149 CA410720174	269	T>K		No	ClinGen ExAC TOPMed gnomAD
rs779580149 CA10107826	269	T>M		No	ClinGen ExAC TOPMed gnomAD
rs201295568 CA10107824	270	C>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1455587549 CA410720165	271	A>P		No	ClinGen gnomAD
rs1455587549 CA410720163	271	A>T		No	ClinGen gnomAD
CA410720159 rs1340162260	272	V>M		No	ClinGen TOPMed
rs1387750044 CA410720142	274	A>V		No	ClinGen gnomAD
CA10107823 rs141710957	275	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA322183241 rs112098524	276	F>C		No	ClinGen Ensembl
CA410720120 rs1180908918	278	T>A		No	ClinGen TOPMed gnomAD
CA410720116 rs1472879496	278	T>I		No	ClinGen TOPMed gnomAD
CA410720118 rs1472879496	278	T>N		No	ClinGen TOPMed gnomAD
rs1180908918 CA410720119	278	T>P		No	ClinGen TOPMed gnomAD
rs904408236 CA322183215	279	V>A		No	ClinGen gnomAD
rs751472807 COSM1190389 CA10107821	279	V>M	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA410720102 rs1568972631	281	I>V		No	ClinGen Ensembl
CA10107818 rs753897004	282	P>A		No	ClinGen ExAC gnomAD
rs760976924 CA10107816	283	E>K		No	ClinGen ExAC gnomAD
CA10107815 rs773751803	285	T>I		No	ClinGen ExAC gnomAD
CA410720074 rs773751803	285	T>S		No	ClinGen ExAC gnomAD
CA10107814 rs772542823	286	K>E		No	ClinGen ExAC gnomAD
rs1186760954 CA410720070	286	K>R		No	ClinGen TOPMed
CA410720064 rs1364422228	287	Q>*		No	ClinGen gnomAD
rs762192720 CA10107812	288	V>M		No	ClinGen ExAC gnomAD
rs774754992 CA10107811	290	K>N		No	ClinGen ExAC gnomAD
rs769143243 CA10107810	291	A>D		No	ClinGen ExAC gnomAD
CA410720019 rs1167981681	294	E>K		No	ClinGen TOPMed
CA10107807 rs199875413	297	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774972671 CA10107808	297	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1310400719 CA410719939	298	S>F		No	ClinGen gnomAD
CA410719897 rs1305874437	301	Y>C		No	ClinGen gnomAD
CA410719902 rs1369453609	301	Y>H		No	ClinGen gnomAD
rs777620618 CA10107784	302	S>L		No	ClinGen ExAC gnomAD
rs778946386 CA410719839	304	Y>*		No	ClinGen ExAC gnomAD
rs748095921 CA10107782	304	Y>H		No	ClinGen ExAC gnomAD
rs1464715109 CA410719828	305	D>G		No	ClinGen gnomAD
CA410719837 rs1421843833	305	D>N		No	ClinGen TOPMed
CA10107779 rs1555881945	307	E>Q		No	ClinGen Ensembl
CA410719780 rs1177404743	308	T>M		No	ClinGen gnomAD
CA410719758 rs1410219938	310	T>A		No	ClinGen gnomAD
CA410719743 rs1181840851	311	G>D		No	ClinGen gnomAD
rs1483518045 CA410719730	312	H>R		No	ClinGen gnomAD
rs1360399422 CA410719715	313	W>*		No	ClinGen TOPMed
rs767867646 CA10107776	318	V>A		No	ClinGen ExAC TOPMed gnomAD
CA410719649 rs750465120	318	V>L		No	ClinGen ExAC gnomAD
rs750465120 CA10107777	318	V>M		No	ClinGen ExAC gnomAD
rs757491145 CA10107775	319	R>C		No	ClinGen ExAC gnomAD
CA10107773 rs148083810	319	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs148083810 CA10107774	319	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA10107772 rs376910842	320	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA410719628 rs1602516279	320	T>P		No	ClinGen Ensembl
CA410719618 rs1227509349	321	S>N		No	ClinGen gnomAD
rs1350767498 CA410719610	321	S>R		No	ClinGen gnomAD
rs559001105 COSM3800044 COSM3800043 CA10107771	322	R>C	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA10107770 rs765665470	322	R>H		No	ClinGen ExAC gnomAD
CA10107769 rs759059606	323	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759059606 CA322182725	323	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10107768 rs776105376	323	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1050618956 CA322182704	324	H>Y		No	ClinGen Ensembl
rs915386827 CA322182680	325	Q>K		No	ClinGen TOPMed
rs1387025407 CA410719548	326	A>S		No	ClinGen gnomAD
rs770556131 CA10107767	327	M>I		No	ClinGen ExAC gnomAD
CA410719510 rs1473106438	328	A>T		No	ClinGen gnomAD
rs760345390 CA10107766	328	A>V		No	ClinGen ExAC
CA410719467 rs1185676255	331	Y>H		No	ClinGen gnomAD
rs771926138 CA10107764	333	H>Y		No	ClinGen ExAC gnomAD
CA410719388 rs1434182519	335	Q>H		No	ClinGen gnomAD
CA410719404 rs1183620378	335	Q>K		No	ClinGen TOPMed gnomAD
rs1259612864 CA410719332	336	K>E		No	ClinGen TOPMed
rs546691807 CA10107749	338	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA10107748 rs765891509	338	S>I		No	ClinGen ExAC gnomAD
rs1456205103 CA410719312	339	P>S		No	ClinGen TOPMed
CA10107747 rs760056513	340	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1017814460 CA322182557	341	E>*		No	ClinGen TOPMed gnomAD
CA10107746 rs772950878	341	E>D		No	ClinGen ExAC gnomAD
rs1017814460 CA410719301	341	E>K		No	ClinGen TOPMed gnomAD
CA410719294 rs1391782983	342	L>V		No	ClinGen gnomAD
CA10107744 rs761716218	344	E>D		No	ClinGen ExAC TOPMed gnomAD
rs774279036 CA10107743	345	L>P		No	ClinGen ExAC gnomAD
CA410719251 rs368688006	349	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779803285 CA10107738	350	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA410719227 rs1482315803	352	H>Q		No	ClinGen gnomAD
rs746991605 CA10107736	353	F>L		No	ClinGen ExAC gnomAD
TCGA novel	355	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758603658 CA10107734	356	G>E		No	ClinGen ExAC TOPMed gnomAD
rs753126301 CA10107733	357	P>L		No	ClinGen ExAC
CA410719194 rs1219139721	358	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs77255694 CA10107731	359	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410719190 rs1331335832	359	R>K		No	ClinGen gnomAD
CA410719180 rs1407753115	360	A>V		No	ClinGen gnomAD
rs754365660 CA10107728	363	V>M		No	ClinGen ExAC TOPMed gnomAD
rs766757264 CA10107727	364	T>P		No	ClinGen ExAC gnomAD
rs1170906125 CA410719150	365	C>F		No	ClinGen gnomAD
rs762962119 CA322182508	366	L>F		No	ClinGen Ensembl
CA410719145 rs530996466	366	L>H		No	ClinGen 1000Genomes
CA322182506 rs530996466	366	L>P		No	ClinGen 1000Genomes
rs1471800019 CA410719123	369	V>G		No	ClinGen gnomAD
CA10107724 rs767260472	369	V>M		No	ClinGen ExAC gnomAD
rs891685811 CA322182480	371	E>D		No	ClinGen TOPMed gnomAD
rs1010132982 CA322182482	371	E>K		No	ClinGen Ensembl
CA322182478 rs893893784	372	G>E		No	ClinGen TOPMed
rs1440076135 CA410719108	372	G>R		No	ClinGen gnomAD
CA10107722 rs368434738	374	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs551437772 CA10107721	374	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA410719067 rs1328063421	376	T>I		No	ClinGen gnomAD
CA410719017 rs1433089927	385	E>K		No	ClinGen gnomAD
rs774563430 CA10107695	387	V>L		No	ClinGen ExAC gnomAD
rs1323692104 CA410718981	390	D>E		No	ClinGen TOPMed
rs749723729 CA10107693	390	D>G		No	ClinGen ExAC gnomAD
TCGA novel	390	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10107691 rs148929784	391	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	394	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464101353 CA410718958	394	H>R		No	ClinGen gnomAD
CA10107689 rs781748762	396	D>V		No	ClinGen ExAC gnomAD
CA10107688 rs756828701	398	L>V		No	ClinGen ExAC gnomAD
rs1288912568 CA410718930	399	G>W		No	ClinGen gnomAD
rs752575735	403	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1433195050	408	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	434	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	454	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772630386	455	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1005499939	461	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs201281385	471	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs200994055	490	E>K	Variant assessed as Somatic; 0.001029 impact. [NCI-TCGA]	No	NCI-TCGA
rs749623047	517	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	518	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200053743	532	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs749424626	576	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs142476770	578	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	578	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	589	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_033721 rs447017	602	S>R		No	UniProt dbSNP
VAR_035482	604	P>S	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs779436705	612	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs779892438	613	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q8IZ69

2 regional properties for Q8IZ69

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	73 - 146	IPR000504
domain	TRMT2A, RNA recognition motif	68 - 146	IPR034262

Functions

		Description
EC Number	2.1.1.35	Methyltransferases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
C-methyltransferase activity	Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule.
RNA binding	Binding to an RNA molecule or a portion thereof.
S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes.

1 GO annotations of biological process

Name	Definition
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSENLDNEGP	KPMESCGQES	SSALSCPTVS	VPPAAPAALE	EVEKEGAGAA	TGPGPQPGLY
70	80	90	100	110	120
SYIRDDLFTS	EIFKLELQNV	PRHASFSDVR	RFLGRFGLQP	HKTKLFGQPP	CAFVTFRSAA
130	140	150	160	170	180
ERDKALRVLH	GALWKGRPLS	VRLARPKADP	MARRRRQEGE	SEPPVTRVAD	VVTPLWTVPY
190	200	210	220	230	240
AEQLERKQLE	CEQVLQKLAK	EIGSTNRALL	PWLLEQRHKH	NKACCPLEGV	RPSPQQTEYR
250	260	270	280	290	300
NKCEFLVGVG	VDGEDNTVGC	RLGKYKGGTC	AVAAPFDTVH	IPEATKQVVK	AFQEFIRSTP
310	320	330	340	350	360
YSAYDPETYT	GHWKQLTVRT	SRRHQAMAIA	YFHPQKLSPE	ELAELKTSLA	QHFTAGPGRA
370	380	390	400	410	420
SGVTCLYFVE	EGQRKTPSQE	GLPLEHVAGD	RCIHEDLLGL	TFRISPHAFF	QVNTPAAEVL
430	440	450	460	470	480
YTVIQDWAQL	DAGSMVLDVC	CGTGTIGLAL	ARKVKRVIGV	ELCPEAVEDA	RVNAQDNELS
490	500	510	520	530	540
NVEFHCGRAE	DLVPTLVSRL	ASQHLVAILD	PPRAGLHSKV	ILAIRRAKNL	RRLLYVSCNP
550	560	570	580	590	600
RAAMGNFVDL	CRAPSNRVKG	IPFRPVKAVA	VDLFPQTPHC	EMLILFERVE	HPNGTGVLGP
610	620
HSPPAQPTPG	PPDNTLQETG	TFPSS