AiPD: Autoinhibited Protein Database

Q8IXQ4

Gene name	GPALPP1 (KIAA1704, LSR7, AD029)
Protein name	GPALPP motifs-containing protein 1
Names	Lipopolysaccharide-specific response protein 7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55425
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-177 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

104-177 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IXQ4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IXQ4-F1	Predicted				AlphaFoldDB

292 variants for Q8IXQ4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1566068355 CA388107934	2	A>T		No	ClinGen Ensembl
rs1451653154 CA388107947	3	R>K		No	ClinGen gnomAD
rs767792761 CA6970706	3	R>S		No	ClinGen ExAC gnomAD
TCGA novel	4	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6970707 rs750433831	4	D>H		No	ClinGen ExAC gnomAD
rs749786966 CA6970710	6	I>N		No	ClinGen ExAC
CA388107991 rs1168925714	7	G>R		No	ClinGen gnomAD
rs755545201 CA6970711	8	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6970712 rs151117256	9	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6970714 rs771849272	11	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs748584524 CA6970713	11	P>S		No	ClinGen ExAC gnomAD
rs1468648566 COSM947630 CA388108061	14	F>I	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA388108081 rs1200954156	15	K>N		No	ClinGen TOPMed
rs1426669458 CA388108074	15	K>Q		No	ClinGen TOPMed
CA388108092 rs1367903031	16	A>V		No	ClinGen gnomAD
rs1436496208 CA388108095	17	R>C		No	ClinGen gnomAD
rs1297271258 CA388108098	17	R>H		No	ClinGen gnomAD
rs1012836860 CA249115519	18	G>R		No	ClinGen TOPMed
CA6970717 rs773006887	19	T>I		No	ClinGen ExAC TOPMed gnomAD
CA388108119 rs773006887	19	T>R		No	ClinGen ExAC TOPMed gnomAD
rs746462611 CA6970718	21	E>V		No	ClinGen ExAC gnomAD
rs770372269 CA6970719	22	D>N		No	ClinGen ExAC gnomAD
rs9567515 CA249115553	24	E>*		No	ClinGen gnomAD
rs9567515 CA388108170	24	E>K		No	ClinGen gnomAD
rs1251603564 CA388108184	25	R>Q		No	ClinGen TOPMed
rs1466169861 CA388108182	25	R>W		No	ClinGen TOPMed gnomAD
rs759361277 CA6970721	26	D>N		No	ClinGen ExAC gnomAD
CA6970722 rs769827322	28	S>I		No	ClinGen ExAC TOPMed gnomAD
CA388108217 rs769827322	28	S>T		No	ClinGen ExAC TOPMed gnomAD
rs762739923 CA6970724	29	P>S		No	ClinGen ExAC TOPMed gnomAD
CA388108227 rs1427174103	30	V>I		No	ClinGen TOPMed gnomAD
CA388095530 rs201119186	31	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201119186 CA6970747	31	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767368604 CA6970748	33	P>L		No	ClinGen ExAC gnomAD
rs767368604 CA388095554	33	P>Q		No	ClinGen ExAC gnomAD
TCGA novel	34	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388095560 rs1254239031	34	A>T		No	ClinGen gnomAD
rs866821188 CA249085750	35	L>V		No	ClinGen Ensembl
CA249085753 rs936258691	37	P>A		No	ClinGen Ensembl
CA388095589 rs778253413	37	P>H		No	ClinGen ExAC gnomAD
CA6970751 rs778253413	37	P>R		No	ClinGen ExAC gnomAD
rs1566075396 CA388095630	40	K>N		No	ClinGen Ensembl
CA388095626 rs1405910622	40	K>R		No	ClinGen gnomAD
CA6970753 rs752004227	41	S>T		No	ClinGen ExAC TOPMed gnomAD
CA6970755 rs756855884	42	S>C		No	ClinGen ExAC gnomAD
rs780901562 CA6970756	42	S>N		No	ClinGen ExAC gnomAD
rs1392410720 CA388095668	43	S>R		No	ClinGen TOPMed
rs975848492 CA249085816	44	S>L		No	ClinGen Ensembl
CA388095720 rs1371961749	47	S>L		No	ClinGen gnomAD
COSM1157958 rs1370501447 CA388095776	50	D>N	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6970758 rs769366212	53	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1347144086 CA388095857	54	S>N		No	ClinGen gnomAD
CA388095878 rs1231720927	55	S>C		No	ClinGen gnomAD
CA388095877 COSM947631 rs1231720927	55	S>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs749852854 CA6970760	58	E>K		No	ClinGen ExAC gnomAD
rs774122804 CA6970762	60	G>R		No	ClinGen ExAC
rs1593389449 CA388095979	61	N>Y		No	ClinGen Ensembl
rs374387240 CA6970765	63	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA388096019 rs1489500239	63	E>A		No	ClinGen gnomAD
CA6970764 rs374387240	63	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA388096043 rs1210898729	64	S>F		No	ClinGen gnomAD
CA388096046 rs1453130562	65	E>K		No	ClinGen gnomAD
CA388096082 rs1391204634	66	E>D		No	ClinGen gnomAD
CA388096100 rs765441196	67	D>E		No	ClinGen ExAC TOPMed gnomAD
CA388096093 rs1051193007	67	D>G		No	ClinGen TOPMed gnomAD
rs933953656 CA249085863	67	D>N		No	ClinGen Ensembl
CA249085866 rs1051193007	67	D>V		No	ClinGen TOPMed gnomAD
CA388096146 rs1352459220	70	G>S		No	ClinGen gnomAD
CA388096160 rs1277184165	71	P>A		No	ClinGen TOPMed
TCGA novel	71	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388096158 rs1277184165	71	P>T		No	ClinGen TOPMed
CA388096173 rs1293609294	72	T>A		No	ClinGen gnomAD
rs146416511 CA6970770	72	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1299492481 CA388096183	73	A>T		No	ClinGen gnomAD
rs1566076419 CA388096360	76	Q>*		No	ClinGen Ensembl
rs775699882 CA6970791	79	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs368962766 CA249087507	80	Q>E		No	ClinGen gnomAD
rs140772055 CA249087518	81	D>N		No	ClinGen ESP TOPMed
CA6970793 rs763128161	82	D>Y		No	ClinGen ExAC
rs138421508 CA388096565	84	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6970798 rs138421508	84	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs762040602 CA249087581	85	D>H		No	ClinGen ExAC gnomAD
rs762040602 CA6970799	85	D>N		No	ClinGen ExAC gnomAD
rs1269313452 CA388096614	86	D>H		No	ClinGen gnomAD
CA388096668 rs1214014247	88	D>E		No	ClinGen gnomAD
rs549136323 CA6970800	88	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388096651 rs1451580266	88	D>Y		No	ClinGen gnomAD
rs750797742 CA6970802	90	F>L		No	ClinGen ExAC TOPMed gnomAD
rs762704412	92	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs755746656 CA6970803	95	L>R		No	ClinGen ExAC TOPMed gnomAD
CA388096822 rs1188182309	95	L>V		No	ClinGen gnomAD
rs566815689 CA6970804	97	P>L		No	ClinGen ExAC TOPMed gnomAD
CA388096885 rs1164085981	98	G>V		No	ClinGen TOPMed
CA6970805 rs376629564	104	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1439892569 CA388097034	104	D>N		No	ClinGen gnomAD
rs754500593 CA6970806	106	P>S		No	ClinGen ExAC gnomAD
rs1371384543 CA388097112	107	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6970816 rs780436691	108	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6970817 rs201143423	110	I>L		No	ClinGen ExAC TOPMed gnomAD
CA6970818 rs201143423	110	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6970819 rs774332471	111	I>V		No	ClinGen ExAC gnomAD
rs773617980 CA6970822	116	P>T		No	ClinGen ExAC gnomAD
rs761036042 CA6970823	117	P>R		No	ClinGen ExAC gnomAD
CA249089667 rs941265455	117	P>S		No	ClinGen Ensembl
CA388097936 rs1283691076	120	I>M		No	ClinGen TOPMed gnomAD
CA388097931 rs1219966872	120	I>V		No	ClinGen gnomAD
TCGA novel	121	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388097974 rs1296223569	126	S>G		No	ClinGen TOPMed
CA6970827 rs764774906	126	S>N		No	ClinGen ExAC gnomAD
rs752199424 CA6970828	127	D>G		No	ClinGen ExAC gnomAD
CA388097982 rs1421631210	127	D>Y		No	ClinGen TOPMed
CA388097993 rs758343811	128	K>N		No	ClinGen ExAC gnomAD
rs777640115 CA6970830	129	G>S		No	ClinGen ExAC gnomAD
rs751340431 CA6970831	131	D>G		No	ClinGen ExAC gnomAD
rs780381420 CA388098026	133	P>L		No	ClinGen ExAC gnomAD
CA6970833 rs780381420	133	P>Q		No	ClinGen ExAC gnomAD
rs1278664846 CA388098024	133	P>S		No	ClinGen gnomAD
rs143551108 CA6970834	134	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388098040 rs1593393357	136	Q>*		No	ClinGen Ensembl
TCGA novel	136	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1271189749 CA388098774	138	T>I		No	ClinGen gnomAD
rs747485988 CA6970859	141	S>G		No	ClinGen ExAC TOPMed gnomAD
CA249094087 rs202130053	141	S>N		No	ClinGen Ensembl
rs747485988 CA388098812	141	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1260816415 CA388098836	142	E>D		No	ClinGen gnomAD
rs771477850 CA6970860	143	D>G		No	ClinGen ExAC gnomAD
CA388098855 rs1189852825	144	E>K		No	ClinGen gnomAD
CA388098883 rs1162888130	145	D>G		No	ClinGen gnomAD
CA6970863 rs377579851	145	D>N		No	ClinGen ExAC gnomAD
rs377579851 CA6970862	145	D>Y		No	ClinGen ExAC gnomAD
rs1230296031 CA388098900	146	I>T		No	ClinGen gnomAD
rs1188284447 CA388098914	147	I>T		No	ClinGen TOPMed
CA6970864 rs775026805	148	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762483039 CA388098943	149	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762483039 CA6970865	149	P>R		No	ClinGen ExAC TOPMed gnomAD
CA388098955 rs1566079717	150	M>T		No	ClinGen Ensembl
CA6970866 rs138236247	150	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6970867 rs200442730	152	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1593397719 CA388099076	157	N>K		No	ClinGen Ensembl
rs761824589 CA6970869	158	Y>C		No	ClinGen ExAC TOPMed
rs1355768306 CA388099083	158	Y>H		No	ClinGen gnomAD
rs767627715 CA6970870	159	N>T		No	ClinGen ExAC gnomAD
CA388099119 rs1242180443	160	V>L		No	ClinGen TOPMed
rs181252018 CA6970873 COSM189018	161	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6970872 rs181252018	161	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6970875 rs758690550	163	E>K		No	ClinGen ExAC gnomAD
rs1011510738 CA249094208	165	E>G		No	ClinGen Ensembl
CA388099216 rs1390124867	166	K>*		No	ClinGen TOPMed
rs747150093 CA6970877	166	K>T		No	ClinGen ExAC TOPMed gnomAD
rs200876314 CA388099237	167	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200876314 CA6970878	167	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA249094215 rs889458652	168	A>P		No	ClinGen Ensembl
CA388099260 rs542957802	169	Q>L		No	ClinGen gnomAD
CA249094217 rs542957802	169	Q>P		No	ClinGen gnomAD
CA388099259 rs542957802	169	Q>R		No	ClinGen gnomAD
rs1168405576 CA388099269	170	R>K		No	ClinGen TOPMed
rs551869859 CA249094219	171	M>I		No	ClinGen gnomAD
rs143717761 CA6970879	172	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs77395794 CA6970880	173	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1362624582 CA388099304	173	E>Q		No	ClinGen gnomAD
rs770084225 CA388099332	175	L>P		No	ClinGen ExAC TOPMed gnomAD
rs770084225 CA6970881	175	L>R		No	ClinGen ExAC TOPMed gnomAD
CA6970882 rs371089645	176	T>A		No	ClinGen ESP ExAC gnomAD
rs1310741661 CA388099352	177	K>N		No	ClinGen gnomAD
rs752693280 CA6970883	178	G>E		No	ClinGen ExAC gnomAD
rs997872756 CA249094263	178	G>R		No	ClinGen TOPMed gnomAD
CA6970909 rs772823123	181	D>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	182	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs267603830 CA249094742	182	S>L		No	ClinGen TOPMed
rs952884921 CA249094771	184	K>Q		No	ClinGen TOPMed
rs1227982732 CA388099547	185	P>L		No	ClinGen TOPMed
CA388099555 rs1452959625	186	I>V		No	ClinGen gnomAD
CA388099583 rs1308005776	188	R>G		No	ClinGen Ensembl
CA388099591 rs1593398397	188	R>I		No	ClinGen Ensembl
CA6970913 rs147252479	191	W>R		No	ClinGen ESP ExAC gnomAD
CA388099676 rs1397458499	193	T>I		No	ClinGen gnomAD
rs201175008 CA249094782	195	L>P		No	ClinGen Ensembl
rs568880282 CA6970914	196	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs151309735 CA6970915	197	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762060082 CA6970916	198	E>K		No	ClinGen ExAC gnomAD
CA249094812 rs970025410	201	D>H		No	ClinGen Ensembl
CA6970918 rs750572846	202	F>S		No	ClinGen ExAC TOPMed gnomAD
CA6970920 rs140588373	203	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388099917 rs754090863	204	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6970921 rs754090863	204	L>I		No	ClinGen ExAC TOPMed gnomAD
CA6970922 rs755412992	204	L>P		No	ClinGen ExAC TOPMed gnomAD
CA249094848 rs1035030446	205	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6970923 rs778672412	205	G>R		No	ClinGen ExAC gnomAD
CA6970924 rs747774408	207	R>K		No	ClinGen ExAC gnomAD
rs771904351 CA6970925	208	T>A		No	ClinGen ExAC gnomAD
CA388100002 rs1185546937	209	F>S		No	ClinGen gnomAD
TCGA novel	211	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388100044 rs1318355534	211	R>T		No	ClinGen TOPMed
CA388100075 rs1421092359	212	R>G		No	ClinGen gnomAD
rs777138102 CA388100084	212	R>K		No	ClinGen ExAC TOPMed gnomAD
CA388100092 rs1165014693	212	R>S		No	ClinGen gnomAD
CA6970926 rs777138102	212	R>T		No	ClinGen ExAC TOPMed gnomAD
CA6970927 rs746598000	213	A>G		No	ClinGen ExAC TOPMed gnomAD
CA249094887 rs746598000	213	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1445010413 CA388100203	219	D>V		No	ClinGen TOPMed
rs1389245268 CA388100212	220	R>*		No	ClinGen TOPMed
rs770707629 CA6970928	220	R>Q		No	ClinGen ExAC gnomAD
rs776645654 CA6970929	221	S>T		No	ClinGen ExAC gnomAD
rs1184718108 CA388100250	223	W>*		No	ClinGen TOPMed
CA388100294 rs1388017905	226	T>A		No	ClinGen gnomAD
rs759279965 CA249094913	226	T>I		No	ClinGen ExAC TOPMed gnomAD
rs759279965 CA6970930	226	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1292773816 CA388100304	227	P>L		No	ClinGen gnomAD
rs1292773816 CA388100301	227	P>Q		No	ClinGen gnomAD
rs769545631 CA388100299	227	P>S		No	ClinGen ExAC gnomAD
rs769545631 CA6970931	227	P>T		No	ClinGen ExAC gnomAD
rs139281660 CA6970932	229	D>N		No	ClinGen ESP ExAC gnomAD
CA249094937 rs915323277	230	R>G		No	ClinGen gnomAD
rs1285630249 CA388100342	231	E>K		No	ClinGen gnomAD
rs745781463 CA6970952	236	E>D		No	ClinGen ExAC gnomAD
CA388101940 rs1306321106	238	Q>R		No	ClinGen gnomAD
CA6970953 rs769781122 CA249098468	239	E>D		No	ClinGen ExAC gnomAD
rs749083020 CA6970956	240	A>G		No	ClinGen ExAC gnomAD
TCGA novel	240	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749083020 CA6970955	240	A>V		No	ClinGen ExAC gnomAD
rs1436916009 CA388102059	245	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA388102154 rs1367732976	249	E>D		No	ClinGen TOPMed gnomAD
rs1273139158 CA388102210	252	I>M		No	ClinGen gnomAD
rs766454946 CA6970959	252	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201980408 CA6970960	254	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388102230 rs201980408	254	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1176681163 CA388102255	256	R>*		No	ClinGen gnomAD
CA388102257 rs1254872425	256	R>K		No	ClinGen gnomAD
rs1454543436 CA388102270	257	D>H		No	ClinGen gnomAD
CA388102330 rs1427716068	260	L>V		No	ClinGen TOPMed
CA388102362 rs1593404194	262	E>G		No	ClinGen Ensembl
CA6970961 rs760111107	263	Q>H		No	ClinGen ExAC gnomAD
rs1593404216 CA388102394	264	V>G		No	ClinGen Ensembl
CA6970962 rs765915069	264	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	266	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1190753444 CA388102410	266	S>P		No	ClinGen TOPMed
rs1465563646 CA388102428	267	Y>C		No	ClinGen TOPMed
CA388103085 rs1394696356	271	K>E		No	ClinGen gnomAD
CA6970986 rs146604110	274	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388103124 rs1216186689	277	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388103134 rs1335349985	278	D>A		No	ClinGen TOPMed gnomAD
COSM106373 rs139408852 CA249103750	278	D>N	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA388103136 rs1335349985	278	D>V		No	ClinGen TOPMed gnomAD
rs749873272 CA6970989	279	I>T		No	ClinGen ExAC gnomAD
rs375918263 CA6970988	279	I>V		No	ClinGen ESP ExAC gnomAD
rs755640220 CA6970990	280	H>R		No	ClinGen ExAC gnomAD
CA6970991 rs779924349	282	K>E		No	ClinGen ExAC gnomAD
rs956065476 CA249103777	282	K>R		No	ClinGen Ensembl
TCGA novel	282	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	283	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753775576 CA6970992	284	L>F		No	ClinGen ExAC gnomAD
rs1194465234 CA388103186	285	K>N		No	ClinGen TOPMed
rs1190108466 CA388103221	290	E>D		No	ClinGen gnomAD
rs1045069851 CA249103786	292	K>E		No	ClinGen TOPMed gnomAD
CA388103244 rs1251743673	293	N>K		No	ClinGen TOPMed
rs754922021 CA6970993	293	N>S		No	ClinGen ExAC gnomAD
CA388103254 rs1163282915	295	P>A		No	ClinGen gnomAD
CA6970994 rs140198634	295	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6970995 rs571780303	300	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA388103291 rs571780303	300	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs771121202 CA6970996	302	D>A		No	ClinGen ExAC gnomAD
rs781578978 COSM1367014 CA6970997	303	R>C	large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6970998 rs745895343	303	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1440859246 CA388103322	305	K>E		No	ClinGen Ensembl
rs1227988962 CA388103337	307	L>V		No	ClinGen TOPMed
CA249103841 rs865930227	308	K>R		No	ClinGen Ensembl
rs770026778 CA6970999	309	V>I		No	ClinGen ExAC gnomAD
rs367606015 CA6971002	311	R>Q		No	ClinGen ESP ExAC gnomAD
rs778797647 CA6971001	311	R>W		No	ClinGen ExAC
rs1330161363 CA388103815	312	F>S		No	ClinGen gnomAD
CA388103822 rs1318672040	313	D>N		No	ClinGen gnomAD
rs1239441247 CA388103848	315	A>T		No	ClinGen gnomAD
CA6971004 rs372113948	317	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6971005 rs143924848	319	A>T		No	ClinGen ESP ExAC gnomAD
CA388103903 rs1371521005	319	A>V		No	ClinGen TOPMed
CA6971006 rs554127017	320	L>I		No	ClinGen 1000Genomes ExAC gnomAD
CA6971009 rs760357344	321	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1566086213	323	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	324	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	324	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388103968 rs765851352	325	R>*		No	ClinGen ExAC TOPMed gnomAD
rs765851352 CA6971010	325	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1015373932 CA249103906	325	R>T		No	ClinGen TOPMed
CA6971011 rs753349879	326	E>K		No	ClinGen ExAC gnomAD
TCGA novel	331	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388104088 rs1378820068	333	H>R		No	ClinGen gnomAD
rs1375751912 CA388104123	335	K>T		No	ClinGen gnomAD
CA388104138 rs1566086249	336	G>R		No	ClinGen Ensembl
CA6971015 rs140810909	337	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758291758 CA388104177	338	M>R		No	ClinGen ExAC gnomAD
CA6971016 rs758291758	338	M>T		No	ClinGen ExAC gnomAD
rs543697222 CA6971017	340	L>*		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with Q8IXQ4

1 regional properties for Q8IXQ4

Type	Name	Position	InterPro Accession
domain	Domain of unknown function DUF3752	196 - 332	IPR022226

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q69ZC8	Gpalpp1	GPALPP motifs-containing protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MARDLIGPAL	PPGFKARGTA	EDEERDPSPV	AGPALPPNYK	SSSSDSSDSD	EDSSSLYEEG
70	80	90	100	110	120
NQESEEDDSG	PTARKQRKNQ	DDDDDDDDGF	FGPALPPGFK	KQDDSPPRPI	IGPALPPGFI
130	140	150	160	170	180
KSTQKSDKGR	DDPGQQETDS	SEDEDIIGPM	PAKGPVNYNV	TTEFEKRAQR	MKEKLTKGDD
190	200	210	220	230	240
DSSKPIVRES	WMTELPPEMK	DFGLGPRTFK	RRADDTSGDR	SIWTDTPADR	ERKAKETQEA
250	260	270	280	290	300
RKSSSKKDEE	HILSGRDKRL	AEQVSSYNES	KRSESLMDIH	HKKLKSKAAE	DKNKPQERIP
310	320	330
FDRDKDLKVN	RFDEAQKKAL	IKKSRELNTR	FSHGKGNMFL