Q8IXH7

PR
Gene name
NELFCD (NELFD, TH1, TH1L, HSPC130)
Protein name
Negative elongation factor C/D
Names
NELF-C/D, TH1-like protein
Species
Homo sapiens (Human)
KEGG Pathway
hsa:51497
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q8IXH7

Entry ID Method Resolution Chain Position Source
5L3X X-ray 275 A B 186-590 PDB
6GML EM 320 A W 10-590 PDB
7PKS EM 360 A W 1-590 PDB
7YCX EM 418 A g 1-590 PDB
8RBX EM 410 A w 10-590 PDB
AF-Q8IXH7-F1 Predicted AlphaFoldDB

No variants for Q8IXH7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8IXH7

No associated diseases with Q8IXH7

No regional properties for Q8IXH7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8IXH7

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
NELF complex A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
negative regulation of transcription elongation by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5GFY4 NELFCD Negative elongation factor D Sus scrofa (Pig) PR
10 20 30 40 50 60
MAGAVPGAIM DEDYYGSAAE WGDEADGGQQ EDDSGEGEDD AEVQQECLHK FSTRDYIMEP
70 80 90 100 110 120
SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK
130 140 150 160 170 180
SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS
190 200 210 220 230 240
DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKNLPEFAKM VCHGEHTYLF
250 260 270 280 290 300
AQAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML
310 320 330 340 350 360
SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL
370 380 390 400 410 420
AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF
430 440 450 460 470 480
PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE
490 500 510 520 530 540
HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV
550 560 570 580
IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN