Q8IX19

PR
Gene name
MCEMP1 (C19orf59)
Protein name
Mast cell-expressed membrane protein 1
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:199675
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8IX19

Entry ID Method Resolution Chain Position Source
AF-Q8IX19-F1 Predicted AlphaFoldDB

3 variants for Q8IX19

Variant ID(s) Position Change Description Diseaes Association Provenance
rs8111596
VAR_059697
CA9144637
 129 V>I No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_030180
rs72996468
CA9144691
 167 I>V No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_051159
rs10409343
CA9144696
 175 L>V No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD

No associated diseases with Q8IX19

No regional properties for Q8IX19

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8IX19

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
specific granule membrane The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
tertiary granule membrane The lipid bilayer surrounding a tertiary granule.

1 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D8U6 Mcemp1 Mast cell-expressed membrane protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEVEEIYKHQ EVKMQAPAFR DKKQGVSAKN QGAHDPDYEN ITLAFKNQDH AKGGHSRPTS
70 80 90 100 110 120
QVPAQCRPPS DSTQVPCWLY RAILSLYILL ALAFVLCIIL SAFIMVKNAE MSKELLGFKR
130 140 150 160 170 180
ELWNVSNSVQ ACEERQKRGW DSVQQSITMV RSKIDRLETT LAGIKNIDTK VQKILEVLQK
MPQSSPQ