AiPD: Autoinhibited Protein Database

Q8IVV7

Gene name	GID4 (C17orf39, VID24)
Protein name	Glucose-induced degradation protein 4 homolog
Names	Vacuolar import and degradation protein 24 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79018
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-81 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

23 structures for Q8IVV7

Entry ID	Method	Resolution	Chain	Position	Source
6CCR	X-ray	160 A	A	116-300	PDB
6CCT	X-ray	240 A	A	124-289	PDB
6CCU	X-ray	175 A	A	116-300	PDB
6CD8	X-ray	160 A	A/B	124-289	PDB
6CD9	X-ray	155 A	A	124-289	PDB
6CDC	X-ray	175 A	A	124-289	PDB
6CDG	X-ray	160 A	A	124-289	PDB
6WZX	X-ray	175 A	A/B	124-289	PDB
6WZZ	X-ray	160 A	A	124-289	PDB
7NSC	EM	330 A	D	1-300	PDB
7Q4Y	X-ray	308 A	A/B	100-300	PDB
7Q50	X-ray	316 A	A	121-290	PDB
7SLZ	X-ray	197 A	A	124-289	PDB
7U3E	X-ray	185 A	A/B	124-289	PDB
7U3F	X-ray	230 A	A	124-289	PDB
7U3G	X-ray	224 A	A	124-289	PDB
7U3H	X-ray	180 A	A	124-289	PDB
7U3I	X-ray	199 A	A/B	124-289	PDB
7U3J	X-ray	164 A	A	124-289	PDB
7U3K	X-ray	220 A	A	124-289	PDB
7U3L	X-ray	229 A	A	124-289	PDB
8V1P	X-ray	221 A	A	124-289	PDB
AF-Q8IVV7-F1	Predicted				AlphaFoldDB

186 variants for Q8IVV7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1235158213 CA398580991	3	A>V		No	ClinGen gnomAD
rs889280811 CA288419051	4	R>Q		No	ClinGen Ensembl
CA288419071 rs1032543574	8	G>R		No	ClinGen Ensembl
rs956950340 CA288419078	10	G>R		No	ClinGen gnomAD
rs553766703 CA8422050	11	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186674984 CA8422051	18	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398581126 rs186674984	18	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1487775591 CA398581133	19	C>R		No	ClinGen gnomAD
CA398581167 rs988567617	22	V>F		No	ClinGen TOPMed
rs988567617 CA288419092	22	V>I		No	ClinGen TOPMed
CA398581181 rs1248583561	23	P>L		No	ClinGen TOPMed
rs1451181632 CA398581178	23	P>S		No	ClinGen TOPMed
CA398581184 rs1182695949	24	G>R		No	ClinGen TOPMed
rs1459836808 CA398581193	25	S>P		No	ClinGen TOPMed
rs1209727327 CA398581208	26	R>L		No	ClinGen TOPMed gnomAD
rs1209727327 CA398581209	26	R>P		No	ClinGen TOPMed gnomAD
rs369896915 CA8422052	30	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398581241 rs369896915	30	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398581254 rs1187074288	31	R>C		No	ClinGen gnomAD
CA288419108 rs971226127	31	R>P		No	ClinGen TOPMed gnomAD
CA398581256 rs1187074288	31	R>S		No	ClinGen gnomAD
rs1344870465 CA398581290	34	R>L		No	ClinGen TOPMed
CA288419134 rs927153372	35	R>G		No	ClinGen TOPMed gnomAD
rs937141107 CA288419138	35	R>K		No	ClinGen Ensembl
CA398581301 rs1452325956	36	Q>*		No	ClinGen TOPMed
rs984736907 CA288419148	37	R>P		No	ClinGen TOPMed
rs984736907 CA398581317	37	R>Q		No	ClinGen TOPMed
CA288419153 rs909144033	38	A>E		No	ClinGen TOPMed gnomAD
rs1348157956 CA398581341	40	G>D		No	ClinGen gnomAD
rs751616570 CA8422053	40	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1012350685 CA288419185	43	S>P		No	ClinGen TOPMed gnomAD
rs1457488664 CA398581378	44	R>P		No	ClinGen TOPMed gnomAD
CA288419189 rs1049247858	46	H>P		No	ClinGen TOPMed gnomAD
rs922879032 CA288419197	46	H>Q		No	ClinGen TOPMed
rs1388287942 CA398581411	48	A>P		No	ClinGen TOPMed gnomAD
rs531574702 CA288419223	49	R>L		No	ClinGen 1000Genomes TOPMed gnomAD
rs531574702 CA288419212	49	R>P		No	ClinGen 1000Genomes TOPMed gnomAD
CA398581427 rs1245863567	50	A>T		No	ClinGen TOPMed
rs1409625422 CA398581440	51	R>L		No	ClinGen TOPMed gnomAD
CA398581441 rs1409625422	51	R>P		No	ClinGen TOPMed gnomAD
rs1306433609 CA398581457	53	G>C		No	ClinGen TOPMed
rs1597685500 CA398581470	54	L>P		No	ClinGen Ensembl
CA398581480 rs1597685517	55	S>F		No	ClinGen Ensembl
CA398581485 rs1318358699	56	L>F		No	ClinGen TOPMed gnomAD
rs1597685531 CA398581488	56	L>P		No	ClinGen Ensembl
rs1567582590 CA398581516	59	T>I		No	ClinGen Ensembl
CA398581511 rs1445183315	59	T>P		No	ClinGen TOPMed gnomAD
rs1183862074 CA398581520	60	L>F		No	ClinGen TOPMed
CA398581523 rs1483210141	60	L>H		No	ClinGen TOPMed
CA398581524 rs1483210141	60	L>P		No	ClinGen TOPMed
rs1267548943 CA398581557	63	S>P		No	ClinGen TOPMed
rs1038896729 CA288419242	64	R>C		No	ClinGen TOPMed gnomAD
rs1319357393 CA398581574	64	R>H		No	ClinGen gnomAD
TCGA novel	64	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs894559468 CA288419252	65	A>E		No	ClinGen TOPMed
CA398581579 rs1243455060	65	A>T		No	ClinGen gnomAD
rs1286897078 CA398581602	66	A>V		No	ClinGen TOPMed
rs564429104 CA288419258	67	A>V		No	ClinGen 1000Genomes gnomAD
rs535142636 CA288419275	69	V>A		No	ClinGen TOPMed gnomAD
CA398581637 rs747919270	69	V>F		No	ClinGen ExAC TOPMed gnomAD
rs747919270 CA8422057	69	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1411914709 CA398581668	71	L>F		No	ClinGen gnomAD
rs533427067 CA8422058	72	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8422059 rs546695787	73	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398581707 rs1597685694	73	L>P		No	ClinGen Ensembl
CA8422060 rs748773460	74	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8422062 rs775970305	75	P>R		No	ClinGen ExAC TOPMed gnomAD
CA288419298 rs901476160	75	P>S		No	ClinGen TOPMed gnomAD
CA398581748 rs1290214061	76	A>S		No	ClinGen gnomAD
CA398581755 rs1376528231	76	A>V		No	ClinGen gnomAD
CA288419305 rs1005076763	77	L>M		No	ClinGen Ensembl
rs747481250 CA8422063	77	L>P		No	ClinGen ExAC gnomAD
CA8422064 rs769053973	78	A>V		No	ClinGen ExAC TOPMed gnomAD
CA288419320 rs933099340	80	G>V		No	ClinGen Ensembl
rs1208144679 CA398581818	81	D>H		No	ClinGen TOPMed gnomAD
CA8422066 rs762112011	81	D>V		No	ClinGen ExAC gnomAD
rs1208144679 CA398581816	81	D>Y		No	ClinGen TOPMed gnomAD
rs1330174550 CA398581844	82	P>L		No	ClinGen TOPMed gnomAD
CA398581889 rs1266623731	85	P>T		No	ClinGen TOPMed
TCGA novel	86	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8422068 rs773630948	87	R>H		No	ClinGen ExAC gnomAD
rs1330024154 CA398581947	89	E>K		No	ClinGen TOPMed
CA398582000 rs1262781665	91	P>L		No	ClinGen TOPMed
rs1258397473 CA398582032	93	P>L		No	ClinGen gnomAD
rs751607901 CA398582048	95	G>R		No	ClinGen ExAC TOPMed gnomAD
rs751607901 COSM3402642 CA8422071	95	G>S	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1411171337 CA398582066	96	A>S		No	ClinGen gnomAD
rs759471091 CA288419381	98	A>G		No	ClinGen ExAC TOPMed gnomAD
rs759471091 CA8422074	98	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1161105911 CA398582109	99	A>V		No	ClinGen gnomAD
rs1357059384 CA398582120	101	A>T		No	ClinGen gnomAD
rs752508173 CA8422077	103	S>L		No	ClinGen ExAC gnomAD
CA398582166 rs777389039	105	I>M		No	ClinGen ExAC TOPMed
CA398582160 rs1356760005	105	I>V		No	ClinGen gnomAD
rs1425240402 CA398582186	108	P>S		No	ClinGen TOPMed
CA398582206 rs1288200102	110	I>V		No	ClinGen TOPMed gnomAD
rs1010568648 CA288419416	111	N>S		No	ClinGen TOPMed
CA8422081 rs756907498	113	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1277004671 CA398582251	113	Q>R		No	ClinGen gnomAD
rs1311792554 CA398582277	115	P>L		No	ClinGen gnomAD
rs1482083189 CA398582373	124	S>G		No	ClinGen gnomAD
rs377621102 CA398582386	125	G>C		No	ClinGen ESP TOPMed gnomAD
rs377621102 CA288419450	125	G>S		No	ClinGen ESP TOPMed gnomAD
CA288419460 rs1032447528	126	S>C		No	ClinGen Ensembl
rs781586887 CA8422085	129	R>H		No	ClinGen ExAC gnomAD
CA8422086 rs748535840	131	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA398582456 rs1432417586	131	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	134	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs975539508 CA288419477	144	V>G		No	ClinGen TOPMed
CA398583085 rs764917589	147	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA8422119 rs761634608	147	H>R		No	ClinGen ExAC gnomAD
CA398583091 rs1389150572	148	V>A		No	ClinGen TOPMed
rs750112471 CA8422121 COSM976179	148	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs758076439 CA8422122	149	D>N		No	ClinGen ExAC gnomAD
rs765753088 CA8422124	150	T>K		No	ClinGen ExAC TOPMed gnomAD
CA8422123 rs765753088	150	T>M		No	ClinGen ExAC TOPMed gnomAD
CA398583121 rs1406510354	151	G>E		No	ClinGen TOPMed gnomAD
rs1406510354 CA398583124	151	G>V		No	ClinGen TOPMed gnomAD
CA288421270 rs112996306	152	N>S		No	ClinGen Ensembl
CA398583216 rs1157075473	160	K>N		No	ClinGen TOPMed
CA398583245 rs1321386564	163	G>D		No	ClinGen gnomAD
rs530802625 CA8422149	167	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1485680786 CA398572682	169	P>R		No	ClinGen gnomAD
rs1250231709 CA398572699	171	L>F		No	ClinGen gnomAD
rs1264041250 CA398572727	173	T>I		No	ClinGen TOPMed
CA398572758 rs758509286	176	E>*		No	ClinGen ExAC TOPMed gnomAD
CA8422152 rs758509286	176	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	177	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398572793 rs1477023288	179	I>K		No	ClinGen gnomAD
rs1192460626 CA398572803	180	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8422155 rs768778982	181	S>G		No	ClinGen ExAC gnomAD
CA398572812 rs144872624	181	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA398572816 rs1166253296	181	S>R		No	ClinGen gnomAD
CA8422156 rs144872624	181	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398572828 rs1215025561	182	K>N		No	ClinGen TOPMed
TCGA novel	183	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA288375951 rs146677351	184	H>P		No	ClinGen Ensembl
TCGA novel	184	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8422158 rs769796611	185	P>R		No	ClinGen ExAC gnomAD
TCGA novel	187	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	189	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138700962 CA8422159	189	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1454415687 CA398572977	195	E>D		No	ClinGen TOPMed
rs1383045516 CA398572999	197	V>D		No	ClinGen TOPMed
rs762847388 CA8422160	199	R>Q		No	ClinGen ExAC gnomAD
rs1409183480 CA398573029	199	R>W		No	ClinGen gnomAD
CA398576420 rs1408493697	207	A>S		No	ClinGen gnomAD
TCGA novel	209	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374432386 CA398576465	210	Q>E		No	ClinGen gnomAD
CA288378314 rs1015548587	210	Q>R		No	ClinGen Ensembl
rs1225837408 COSM976180 CA398576492	211	Y>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA398576508 rs1311889156	212	A>T		No	ClinGen gnomAD
CA398576514 rs1235084408	212	A>V		No	ClinGen gnomAD
CA288378317 rs866971433	214	S>L		No	ClinGen Ensembl
CA8422203 rs768276699	217	S>L		No	ClinGen ExAC gnomAD
CA398576622 rs1232249563	219	D>G		No	ClinGen gnomAD
CA398576643 rs1567588708	220	F>L		No	ClinGen Ensembl
rs763403472 CA8422205	223	E>K		No	ClinGen ExAC TOPMed gnomAD
CA288378330 rs961266678	224	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1312815100 CA398576721	225	L>V		No	ClinGen TOPMed
CA8422206 rs766905777	226	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8422207 rs141270542	227	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA288378337 rs560517467	229	D>N		No	ClinGen Ensembl
rs200321621 CA8422209	231	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs200321621 CA8422210	231	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567589413 CA398577520	243	D>G		No	ClinGen Ensembl
TCGA novel	252	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398577602 rs1363379650	253	S>A		No	ClinGen gnomAD
TCGA novel	254	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775732469 CA8422228	261	C>S		No	ClinGen ExAC gnomAD
CA8422229 rs760900535	262	F>V		No	ClinGen ExAC TOPMed gnomAD
CA398577704 rs1471141922	266	A>P		No	ClinGen TOPMed
CA398577734 rs1216203904	269	I>V		No	ClinGen gnomAD
rs764253071 COSM3378092 CA8422230	275	H>R	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1021022672 CA288380082	278	S>L		No	ClinGen Ensembl
CA8422231 rs753921949	280	W>R		No	ClinGen ExAC gnomAD
CA8422257 rs754791891	285	N>I		No	ClinGen ExAC gnomAD
CA8422258 rs754791891	285	N>S		No	ClinGen ExAC gnomAD
rs150762880 CA8422256	285	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA8422259 rs752280108	287	T>A		No	ClinGen ExAC gnomAD
CA398578129 rs752280108	287	T>S		No	ClinGen ExAC gnomAD
CA398578149 rs1365431309	289	V>I		No	ClinGen TOPMed
CA8422260 rs755777454	290	P>S		No	ClinGen ExAC gnomAD
rs201429044 CA288381859	291	E>G		No	ClinGen Ensembl
rs1314671213 CA398578188	294	A>V		No	ClinGen TOPMed gnomAD
rs1333710659 CA398578191	295	P>S		No	ClinGen gnomAD

No associated diseases with Q8IVV7

3 regional properties for Q8IVV7

Type	Name	Position	InterPro Accession
domain	TGF-beta, propeptide	22 - 227	IPR001111
domain	Transforming growth factor-beta, C-terminal	299 - 414	IPR001839
conserved_site	Transforming growth factor beta, conserved site	335 - 350	IPR017948

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
ubiquitin ligase complex	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

1 GO annotations of molecular function

Name	Definition
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

1 GO annotations of biological process

Name	Definition
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MCARGQVGRG	TQLRTGRPCS	QVPGSRWRPE	RLLRRQRAGG	RPSRPHPARA	RPGLSLPATL
70	80	90	100	110	120
LGSRAAAAVP	LPLPPALAPG	DPAMPVRTEC	PPPAGASAAS	AASLIPPPPI	NTQQPGVATS
130	140	150	160	170	180
LLYSGSKFRG	HQKSKGNSYD	VEVVLQHVDT	GNSYLCGYLK	IKGLTEEYPT	LTTFFEGEII
190	200	210	220	230	240
SKKHPFLTRK	WDADEDVDRK	HWGKFLAFYQ	YAKSFNSDDF	DYEELKNGDY	VFMRWKEQFL
250	260	270	280	290
VPDHTIKDIS	GASFAGFYYI	CFQKSAASIE	GYYYHRSSEW	YQSLNLTHVP	EHSAPIYEFR