Q8IS19

PR
Gene name
gefD (RasGEFD, DDB_G0289667)
Protein name
Ras guanine nucleotide exchange factor D
Names
RhoGAP domain-containing protein D
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0289667
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

343-433 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8IS19

Entry ID Method Resolution Chain Position Source
AF-Q8IS19-F1 Predicted AlphaFoldDB

No variants for Q8IS19

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8IS19

No associated diseases with Q8IS19

3 regional properties for Q8IS19

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 27 - 224 IPR000198
domain Ras-like guanine nucleotide exchange factor, N-terminal 236 - 363 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 429 - 664 IPR001895

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

3 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
response to differentiation-inducing factor 1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGNSKQIKRS LTGSILLKKQ ISQIFFKKLE SIFGIALAED TSDRLMDYLN KSIDYLLDHS
70 80 90 100 110 120
VIEGLFSIEI EESKLKSTIE SIESTLITDF SLTTDPCYVA STFILYFSKL PNLLLSKISS
130 140 150 160 170 180
QLIHSVEISH EEYRINVIRS LLYSLPLQNR NILKMVLHFL KKFSLACNNN NNNNSENNNT
190 200 210 220 230 240
IVEDIEVQSA YNRFTKAFMS TTPGNFEISC KAIRLMVMDI DEFDKLPQDI QYMVKDGESI
250 260 270 280 290 300
VKAATFDRLV EKLFDLSYGF KDPDYNYTVF HTYDYYTTSV ELLGKIVHYY RIACTLTTKL
310 320 330 340 350 360
QMEVSITILS VAMFWMKIHH NHLMTDLQFL QKLKIFLDSV PQVPPTQVTY FTYFQTFFKP
370 380 390 400 410 420
VIEPLKPLYE RGNSFLGPNL TQSSGTSKKK NQLIEKMMIN NNINNNNNIN NNVNSNSNNN
430 440 450 460 470 480
FNNNIDIDIY NIGSNIIAQQ ITIIDNEMLM AIPPSQFLHK SFSKESKSPQ FHDMVSKFNE
490 500 510 520 530 540
WARWTSSEIL SKEKLVERVV TLSFFIDLAK SCVELGNYNA ANAIVGGLNH SSISRLKLTW
550 560 570 580 590 600
ERLSTKVTQD YDRLLSLFDL SMNYKNYRDE IKSTKAKIIP YLGLFPKDLI AIEEGNDNFT
610 620 630 640 650 660
NNNLINTEKF RLLYQTIKKI QSYQQPLFTF KTSEPIKQYL KNISNGLSEE KDFHSISHKL
EPRQQQTQ