Q8IDR3

PR
Gene name
MyoA
Protein name
Myosin-A
Names
PfMyoA
Species
Plasmodium falciparum (isolate 3D7)
KEGG Pathway
pfa:PF3D7_1342600
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

17 structures for Q8IDR3

Entry ID Method Resolution Chain Position Source
4AOM X-ray 194 A T 799-816 PDB
4MZJ X-ray 147 A T 799-816 PDB
4MZK X-ray 182 A T 799-816 PDB
4MZL X-ray 201 A C/D 800-816 PDB
4R1E X-ray 198 A B 803-816 PDB
6I7D X-ray 282 A A/B/C/D 1-768 PDB
6I7E X-ray 349 A A 1-768 PDB
6TU7 EM 310 A AP1/GP1 2-818 PDB
6YCX X-ray 399 A A/B 1-818 PDB
6YCY X-ray 255 A A 1-818 PDB
6YCZ X-ray 327 A A 1-818 PDB
6ZN3 X-ray 251 A C/F/I/L/O 775-816 PDB
7ALN EM 377 A F 1-818 PDB
8A12 X-ray 203 A A 1-818 PDB
8CDM X-ray 235 A A 1-818 PDB
8CDQ X-ray 221 A A 1-818 PDB
AF-Q8IDR3-F1 Predicted AlphaFoldDB

No variants for Q8IDR3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8IDR3

No associated diseases with Q8IDR3

2 regional properties for Q8IDR3

Type Name Position InterPro Accession
domain Myosin head, motor domain 91 - 772 IPR001609
domain Class XIV myosin, motor domain 111 - 759 IPR036044

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Tightly associated with the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
inner membrane pellicle complex A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell.
myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
pellicle The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytoskeletal motor activity Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVTNEEIKT ASKIVRRVSN VEAFDKSGSV FKGYQIWTDI SPTIENDPNI MFVKCVVQQG
70 80 90 100 110 120
SKKEKLTVVQ IDPPGTGTPY DIDPTHAWNC NSQVDPMSFG DIGLLNHTNI PCVLDFLKHR
130 140 150 160 170 180
YLKNQIYTTA VPLIVAINPY KDLGNTTNEW IRRYRDTADH TKLPPHVFTC AREALSNLHG
190 200 210 220 230 240
VNKSQTIIVS GESGAGKTEA TKQIMRYFAS SKSGNMDLRI QTAIMAANPV LEAFGNAKTI
250 260 270 280 290 300
RNNNSSRFGR FMQLVISHEG GIRYGSVVAF LLEKSRIITQ DDNERSYHIF YQFLKGANST
310 320 330 340 350 360
MKSKFGLKGV TEYKLLNPNS TEVSGVDDVK DFEEVIESLK NMELSESDIE VIFSIVAGIL
370 380 390 400 410 420
TLGNVRLIEK QEAGLSDAAA IMDEDMGVFN KACELMYLDP ELIKREILIK VTVAGGTKIE
430 440 450 460 470 480
GRWNKNDAEV LKSSLCKAMY EKLFLWIIRH LNSRIEPEGG FKTFMGMLDI FGFEVFKNNS
490 500 510 520 530 540
LEQLFINITN EMLQKNFVDI VFERESKLYK DEGISTAELK YTSNKEVINV LCEKGKSVLS
550 560 570 580 590 600
YLEDQCLAPG GTDEKFVSSC ATNLKENNKF TPAKVASNKN FIIQHTIGPI QYCAESFLLK
610 620 630 640 650 660
NKDVLRGDLV EVIKDSPNPI VQQLFEGQVI EKGKIAKGSL IGSQFLNQLT SLMNLINSTE
670 680 690 700 710 720
PHFIRCIKPN ENKKPLEWCE PKILIQLHAL SILEALVLRQ LGYSYRRTFE EFLYQYKFVD
730 740 750 760 770 780
IAAAEDSSVE NQNKCVNILK LSGLSESMYK IGKSMVFLKQ EGAKILTKIQ REKLVEWENC
790 800 810
VSVIEAAILK HKYKQKVNKN IPSLLRVQAH IRKKMVAQ