Q8I7J4

PR
Gene name
coq-2 (F57B9.4)
Protein name
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Names
4-HB polyprenyltransferase, Para-hydroxybenzoate--polyprenyltransferase, PHB:PPT, PHB:polyprenyltransferase
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F57B9.4
EC number
2.5.1.39: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8I7J4

Entry ID Method Resolution Chain Position Source
AF-Q8I7J4-F1 Predicted AlphaFoldDB

No variants for Q8I7J4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8I7J4

No associated diseases with Q8I7J4

1 regional properties for Q8I7J4

Type Name Position InterPro Accession
conserved_site UbiA prenyltransferase conserved site 121 - 143 IPR030470

Functions

Description
EC Number 2.5.1.39 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
4-hydroxybenzoate decaprenyltransferase activity Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.
4-hydroxybenzoate nonaprenyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate.
4-hydroxybenzoate octaprenyltransferase activity Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate.
transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).

2 GO annotations of biological process

Name Definition
isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VHS7 Coq2 4-hydroxybenzoate polyprenyltransferase, mitochondrial Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MITRSIGIAR RSNSINCIVG SNTSTSYSLD ESTKRWISTS TKQPMSLIPT ASSLVASSPP
70 80 90 100 110 120
NLKPYLQLMR VDKPIGTWLL YWPCTWSIAM ATPAGQLPSI YMLSLFGAGA FLMRSAGCVI
130 140 150 160 170 180
NDLWDKDFDK KVERTKLRPL ACGSLTEKQA IGLLAGLLSS SLAILLQLNW YSVAVGASSM
190 200 210 220 230 240
ALVVGYPLAK RFTYWPQFVL GLTFNWGALL GWCALKGDLS SSAPFWMYAA ALQWTLIYDT
250 260 270 280 290 300
IYAHQDKADD IMIGVKSTAL RLGADTKKWL SAFGVGTVAS LTACGIASDQ TWPYYVALAA
310 320 330 340 350
TTAQLGWQVG TVDIDNGSDC WDKFKSNSWM GIILFSGIVA STLLKEVFQI LIRPYH