Q8HXX7
Gene name |
GDI1 (QccE-14140, QccE-14779) |
Protein name |
Rab GDP dissociation inhibitor alpha |
Names |
Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1 |
Species |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
KEGG Pathway |
mcf:102142996 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8HXX7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8HXX7-F1 | Predicted | AlphaFoldDB |
No variants for Q8HXX7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8HXX7 | |||||
No associated diseases with Q8HXX7
1 regional properties for Q8HXX7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycerophosphodiester phosphodiesterase domain | 198 - 457 | IPR030395 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
| negative regulation of protein targeting to membrane | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | ELYKRFQLLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | DFKVVEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STETEALASN | LMGMFEKRRF | RKFLVFVANF | DENDPKTFEG | VDPQTTSMRD | VYRKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHALA | LYRTDDYLDQ | PCLETINRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VRKAGQVIRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | AIASTTVETT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGCESQVFC | SCSYDATTHF | ETTCNDIKDI |
| 430 | 440 | ||||
| YKRMAGMAFD | FENMKRKQND | VFGEAEQ |