Q8HDG8

PR
Gene name
RARRES2 (TIG2)
Protein name
Retinoic acid receptor responder protein 2
Names
Chemerin, RAR-responsive protein TIG2, Tazarotene-induced gene 2 protein
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
cge:100689253
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8HDG8

Entry ID Method Resolution Chain Position Source
AF-Q8HDG8-F1 Predicted AlphaFoldDB

No variants for Q8HDG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8HDG8

No associated diseases with Q8HDG8

No regional properties for Q8HDG8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8HDG8

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

8 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of insulin receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin receptor signaling.
regulation of lipid catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKYLLISLAL WLGMVGIHGT ELELSETQRR GLQVALEEFH KHPPVQWAFQ EIGVDNANDM
70 80 90 100 110 120
VFSAGTFVRL EFKLQQTSCF KKDWKNPECK IKANGRKRKC LACIKLDPRG KVLGRMVHCP
130 140 150 160
ILKQGLQQEL QESQCNRITQ AGEDPRSHFF PGQFAFSRAL KHK