Q8GCR4

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Enterococcus faecium (Streptococcus faecium)
KEGG Pathway
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1128-1208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GCR4

Entry ID Method Resolution Chain Position Source
AF-Q8GCR4-F1 Predicted AlphaFoldDB

No variants for Q8GCR4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8GCR4

No associated diseases with Q8GCR4

8 regional properties for Q8GCR4

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 683 - 1068 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 921 - 933 IPR007121
domain RNA polymerase Rpb2, domain 7 1070 - 1144 IPR007641
domain RNA polymerase Rpb2, domain 2 143 - 291 IPR007642-1
domain RNA polymerase Rpb2, domain 2 383 - 417 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 31 - 461 IPR007644
domain RNA polymerase Rpb2, domain 3 476 - 544 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 554 - 621 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSLAGHVVK YGKHRERKSF ARISEVLELP NLIEIQTDSY QWFLDEGLRE MFEDILPIDD
70 80 90 100 110 120
FNGNLSLEFV DYELKEPKYT VAEARAHDAN YSAPLHVTLR LTNRETGEIK AQEVFFGDFP
130 140 150 160 170 180
LMTEQGTFII NGAERVIVSQ LVRSPGVYFH GKVDKNGKEG FGSTVIPNRG AWLEMETDAK
190 200 210 220 230 240
DISYVRIDRT RKIPLTVLVR ALGFGSDDTI FEIFGDSETL RNTVEKDLHK NASDSRTEEG
250 260 270 280 290 300
LKDVYERLRP GEPKTADSSR NLLNARFFDP KRYDLANVGR YKVNKKLDLK TRLLNLTLAE
310 320 330 340 350 360
TLVDPETGEI IVEKGTVLTH QVMETLAPFI DNGLNSVTYY PSEDGVVTDP MTVQVIKVFS
370 380 390 400 410 420
PKDPEREVNV IGNGYPESAV KTVRPADIIA SMSYFLNLME GIGNVDDIDH LGNRRIRSVG
430 440 450 460 470 480
ELLQNQFRIG LARMERVVRE RMSIQDTETL TPQQLINIRP VVASIKEFFG SSQLSQFMDQ
490 500 510 520 530 540
TNPLGELTHK RRLSALGPGG LTRDRAGYEV RDVHYSHYGR MCPIETPEGP NIGLINSLSS
550 560 570 580 590 600
YAKVNKFGFI ETPYRRVDRE TGRVTDQIDY LTADIEDHYI VAQANSPLNE DGTFAQDVVM
610 620 630 640 650 660
ARAQSENLEV SIDKVDYMDV SPKQVVAVAT ACIPFLENDD SNRALMGANM QRQAVPLINP
670 680 690 700 710 720
QAPWVGTGME YKSAHDSGAA LLCKHDGVVE FVDASEIRVR RDNGALDKYA VTKFRRSNSG
730 740 750 760 770 780
TSYNQRPIVH LGEKVEKGDT LADGPSMEQG EMALGQNVLV GFMTWEGYNY EDAIIMSRRL
790 800 810 820 830 840
VKDDVYTSIH IEEYESEARD TKLGPEEITR EIPNVGEDAL KDLDEMGIIR IGAEVQDGDL
850 860 870 880 890 900
LVGKVTPKGV TELSAEERLL HAIFGEKARE VRDTSLRVPH GGGGIVHDVK IFTREAGDEL
910 920 930 940 950 960
SPGVNMLVRV YIVQKRKIHE GDKMAGRHGN KGVVSRIMPE EDMPFLPDGT PIDIMLNPLG
970 980 990 1000 1010 1020
VPSRMNIGQV LELHLGMAAR QLGIHVATPV FDGASDEDVW ETVREAGMAS DAKTILYDGR
1030 1040 1050 1060 1070 1080
TGEPFDGRVS VGVMYMIKLA HMVDDKLHAR SIGPYSLVTQ QPLGGKAQFG GQRFGEMEVW
1090 1100 1110 1120 1130 1140
ALEAYGAAYT LQEILTYKSD DVVGRVKTYE AIVKGEPIPK PGVPESFRVL VKELQSLGLD
1150 1160 1170 1180 1190 1200
MRVLDIKDSE IELRDMDDED DDLITVDALT KFAEQQTAKE LEKKAAEQVE DERQDIIQNF
ETAEDNLD