Q8FZC4

PR
Gene name
leuA
Protein name
2-isopropylmalate synthase
Names
Alpha-IPM synthase, Alpha-isopropylmalate synthase
Species
Brucella suis biovar 1 (strain 1330)
KEGG Pathway
bsi:BS1330_I1560
EC number
2.3.3.13: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8FZC4

Entry ID Method Resolution Chain Position Source
AF-Q8FZC4-F1 Predicted AlphaFoldDB

No variants for Q8FZC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8FZC4

No associated diseases with Q8FZC4

2 regional properties for Q8FZC4

Type Name Position InterPro Accession
conserved_site Isocitrate/isopropylmalate dehydrogenase, conserved site 231 - 250 IPR019818
domain Isopropylmalate dehydrogenase-like domain 2 - 332 IPR024084

Functions

Description
EC Number 2.3.3.13 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIAGTKYAP FPAPQLDDRT WPSKRIEKAP IWCSVDLRDG NQALIDPMGH DRKERMFRLL
70 80 90 100 110 120
IDMGFPEIEI GFPSASQTDF DFCRWAIEQG DVPDDVDLQV LVQCRPELIT RTFEALEGAK
130 140 150 160 170 180
TPIIHFYNST SELQRRVVFA KDVGGIKQIA TDAAKMIMDM AAKAGGGYRF QYSPESFTGT
190 200 210 220 230 240
ELDVALEICN AVIEIVKPTP DNKLIVNLPS TVEMNTPNVY ADQIEWMCRN LDNRESLIIS
250 260 270 280 290 300
LHPHNDRGTG IAATELGLMA GADRVEGTLF GNGERTGNVD VVTLALNMYT QGIDPGLDCT
310 320 330 340 350 360
DINRMKEVYE YSNQLKIAER HPYVGELVYT AFSGSHQDAI NKGMKARRSA NSPVWEVPYL
370 380 390 400 410 420
PIDPQDVGRS YEAIIRINSQ SGKGGIAYIL QADYGLNLPR NLQVEFREII QHITDEEGKE
430 440 450 460 470 480
LPSKRIYEEF QKLYVTQPDA RIKFVDHHTY PDPEQKGRRI LTAEITDNGV TKTIEGKGTG
490 500 510 520 530 540
PIDGFVDALS KYLGVKMSVV DYSEHSLQQG SDASAISYVE MVYPGGKLFG VGINDNIVSA
550
SLEAVVSAAN RVIAK