Q8FTJ5

SS
Gene name
odhI (CE1573)
Protein name
Oxoglutarate dehydrogenase inhibitor
Names
Species
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
KEGG Pathway
cef:CE1573
EC number
Protein Class

Descriptions

The unphosphorylated form of OdhI inhibits the activity of 2-oxoglutarate dehydrogenase, a key enzyme of the TCA cycle. The N-terminal disordered region contains two phosphorylation sites at 14 and 15. Phosphorylation of the residues induces extensive conformational change of OdhI, which results in the release of autoinhibition.

Autoinhibitory domains (AIDs)

1-39 (N-terminal disordered autoinhibitory region) SS

Target domain

66-130 (FHA domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8FTJ5

Entry ID Method Resolution Chain Position Source
AF-Q8FTJ5-F1 Predicted AlphaFoldDB

No variants for Q8FTJ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8FTJ5

No associated diseases with Q8FTJ5

1 regional properties for Q8FTJ5

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 66 - 130 IPR000253

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDNTGTPEP QVETTSVFRA DLLKEMSGAG SAPAATGADN LPAGSALLVV KRGPNAGARF
70 80 90 100 110 120
LLDQPTTTAG RHPESDIFLD DVTVSRRHAE FRINEGEFEV VDVGSLNGTY VNREPRNSQV
130 140
LQTGDEIQIG KFRLVFLAGP AA