Q8FQ22

PR
Gene name
atpA
Protein name
ATP synthase subunit alpha
Names
ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha
Species
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
KEGG Pathway
cef:CE1313
EC number
7.1.2.2: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

472-546 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8FQ22

Entry ID Method Resolution Chain Position Source
AF-Q8FQ22-F1 Predicted AlphaFoldDB

No variants for Q8FQ22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8FQ22

No associated diseases with Q8FQ22

5 regional properties for Q8FQ22

Type Name Position InterPro Accession
domain ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain 152 - 375 IPR000194
domain ATP synthase, alpha subunit, C-terminal 382 - 511 IPR000793
domain ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain 29 - 95 IPR004100
active_site ATPase, alpha/beta subunit, nucleotide-binding domain, active site 366 - 375 IPR020003
domain ATP synthase, F1 complex, alpha subunit nucleotide-binding domain 97 - 378 IPR033732

Functions

Description
EC Number 7.1.2.2 Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proton-transporting ATP synthase activity, rotational mechanism Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAELTISSDE IRSAIANYTS SYSAEASREE VGVVISAADG IAQVSGLPSV MANELLEFPG
70 80 90 100 110 120
GVIGVAQNLD TDSVGVVVLG NYELLKEGDQ VRRTGDVLSI PVGEKFLGRV INPLGQPIDG
130 140 150 160 170 180
LGEIVAEEDR VLELQAPSVL ERQPVEEPMA TGIKAIDAMT PIGRGQRQLI IGDRKTGKTA
190 200 210 220 230 240
VCVDTILNQK ANWETGDKTK QVRCIYVAIG QKGSTIAALR KTLEEQGALE YTTIVAAPAS
250 260 270 280 290 300
DAAGFKWLAP FAGAALAQHW MYQGNHVLVI YDDLTKQAEA YRAISLLLRR PPGREAYPGD
310 320 330 340 350 360
VFYLHSRLLE RAAKLSDDLG AGSITALPII ETKANDVSAF IPTNVISITD GQVFLESDLF
370 380 390 400 410 420
NRGVRPAINV GISVSRVGGA AQTKGMKKVA GSLRLDLAAY RDLEAFATFA SDLDAASKAQ
430 440 450 460 470 480
LERGQRLVQL LIQSENAPQA VEYQIISLWL AGEGAFDNVP VDDVRRFETE LHEYLGSNAP
490 500 510 520 530 540
QVYEQIAGGA VLSDESKETL LQATEQFKGT FQTTDGTRII NEPEVDALDA GQVRKDQLTV
SRKVGK