Q8FLA1

PR
Gene name
kefC
Protein name
Glutathione-regulated potassium-efflux system protein KefC
Names
K(+)/H(+) antiporter
Species
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG Pathway
ecc:c0057
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

540-620 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8FLA1

Entry ID Method Resolution Chain Position Source
AF-Q8FLA1-F1 Predicted AlphaFoldDB

No variants for Q8FLA1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8FLA1

No associated diseases with Q8FLA1

5 regional properties for Q8FLA1

Type Name Position InterPro Accession
domain Dehydrogenase, E1 component 489 - 817 IPR001017
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 103 - 335 IPR001078
domain Transketolase-like, pyrimidine-binding domain 879 - 1080 IPR005475
domain Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal 1084 - 1230 IPR031717
domain 2-oxoglutarate dehydrogenase E1 component, N-terminal domain 5 - 37 IPR032106

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
glutathione-regulated potassium exporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state.
solute:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
toxic substance binding Binding to a toxic substance, a poisonous substance that causes damage to biological systems.

1 GO annotations of biological process

Name Definition
response to methylglyoxal Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSHTLIQAL IYLGSAALIV PIAVRLGLGS VLGYLIAGCI IGPWGLRLVT DAESILHFAE
70 80 90 100 110 120
IGVVLMLFII GLELDPQRLW KLRAAVFGGG ALQMVICGGL LGLFCMLLGL RWQVAELIGM
130 140 150 160 170 180
TLALSSTAIA MQAMNERNLM VTQMGRSAFA VLLFQDIAAI PLVAMIPLLA ASSASTTMGA
190 200 210 220 230 240
FVLSALKVAG ALALVVLLGR YVTRPALRFV ARSGLREVFS AVALFLVFGF GLLLEEVGLS
250 260 270 280 290 300
MAMGAFLAGV LLASSEYRHA LESDIEPFKG LLLGLFFIGV GMSIDFGTLL ENPLRIVILL
310 320 330 340 350 360
LGFLIIKIAM LWLIARPLQV PNKQRRWFAV LLGQGSEFAF VVFGAAQMAN VLEPEWAKSL
370 380 390 400 410 420
TLAVALSMAA TPILLVILNR LEQSSTEEAR EADEIDEEQP RVIIAGFGRF GQITGRLLLS
430 440 450 460 470 480
SGVKMVVLDH DPDHIETLRK FGMKVFYGDA TRMDLLESAG AAKAEVLINA IDDPQTNLQL
490 500 510 520 530 540
TEMVKEHFPH LQIIARARDV DHYIRLRQAG VEKPERETFE GALKTGRLAL ESLGLGPYEA
550 560 570 580 590 600
RERADVFRRF NIQMVEEMAM VENDTKARAA VYKRTSAMLS EIITEDREHL SLIQRHGWQG
610
TEEGKHTGNM ADEPETKPSS