Q8FHC7
Gene name |
rspA (c1971) |
Protein name |
D-galactonate dehydratase family member RspA |
Names |
D-mannonate dehydratase, Starvation sensing protein RspA homolog |
Species |
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
KEGG Pathway |
ecc:c1971 |
EC number |
4.2.1.8: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8FHC7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4IL2 | X-ray | 195 A | A/B/C/D | 1-415 | PDB |
| AF-Q8FHC7-F1 | Predicted | AlphaFoldDB |
No variants for Q8FHC7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8FHC7 | |||||
No associated diseases with Q8FHC7
5 regional properties for Q8FHC7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Mandelate racemase/muconate lactonizing enzyme, N-terminal domain | 22 - 121 | IPR013341 |
| domain | Mandelate racemase/muconate lactonizing enzyme, C-terminal | 139 - 270 | IPR013342 |
| conserved_site | Mandelate racemase/muconate lactonizing enzyme, conserved site | 96 - 121 | IPR018110-1 |
| conserved_site | Mandelate racemase/muconate lactonizing enzyme, conserved site | 220 - 251 | IPR018110-2 |
| domain | Enolase C-terminal domain-like | 206 - 390 | IPR029065 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.8 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| mannonate dehydratase activity | Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate catabolic process | The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| cellular amino acid catabolic process | The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHHDKRCKES | NMKIVKAEVF | VTCPGRNFVT | LKITTEDGIT | GLGDATLNGR | ELSVASYLQD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLCPQLIGRD | AHRIEDIWQF | FYKGAYWRRG | PVTMSAISAV | DMALWDIKAK | AANMPLYQLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGASREGVMV | YCHTTGHSID | EALDDYARHQ | ELGFKAIRVQ | CGIPGMKTTY | GMSKGKGLAY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPATKGQWPE | EQLWSTEKYL | DFMPKLFDAV | RNKFGFDEHL | LHDMHHRLTP | IEAARFGKSI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDYRMFWMED | PTPAENQECF | RLIRQHTVTP | IAVGEVFNSI | WDCKQLIEEQ | LIDYIRTTLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HAGGITGMRR | IADFASLYQV | RTGSHGPSDL | SPVCMAAALH | FDLWVPNFGV | QEYMGYSEQM |
| 370 | 380 | 390 | 400 | 410 | |
| LEVFPHNWTF | DNGYMHPGEK | PGLGIEFDEK | LAAKYPYEPA | YLPVARLEDG | TLWNW |