Q8FD87

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG Pathway
ecc:c3920
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

660-711 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8FD87

Entry ID Method Resolution Chain Position Source
AF-Q8FD87-F1 Predicted AlphaFoldDB

No variants for Q8FD87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8FD87

No associated diseases with Q8FD87

9 regional properties for Q8FD87

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 16 - 144 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 324 - 456 IPR001247-2
domain S1 domain 619 - 690 IPR003029
domain K Homology domain 552 - 617 IPR004087
domain K Homology domain, type 1 556 - 614 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 147 - 210 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 460 - 527 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 242 - 320 IPR015848
domain RNA-binding domain, S1 620 - 690 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNPIVRKFQ YGQHTVTLET GMMARQATAA VMVSMDDTAV FVTVVGQKKA KPGQDFFPLT
70 80 90 100 110 120
VNYQERTYAA GRIPGSFFRR EGRPSEGETL IARLIDRPIR PLFPEGFVNE VQVIATVVSV
130 140 150 160 170 180
NPQVNPDIVA MIGASAALSL SGIPFNGPIG AARVGYINDQ YVLNPTQDEL KESKLDLVVA
190 200 210 220 230 240
GTEAAVLMVE SEAELLSEDQ MLGAVVFGHE QQQVVIQNIN ELVKEAGKPR WDWQPEPVNE
250 260 270 280 290 300
ALNARVAALA EARLSDAYRI TDKQERYAQV DVIKSETIAT LLAEDETLDE NELGEILHAI
310 320 330 340 350 360
EKNVVRSRVL AGEPRIDGRE KDMIRGLDVR TGVLPRTHGS ALFTRGETQA LVTATLGTAR
370 380 390 400 410 420
DAQVLDELMG ERTDTFLFHY NFPPYSVGET GMVGSPKRRE IGHGRLAKRG VLAVMPDMDK
430 440 450 460 470 480
FPYTVRVVSE ITESNGSSSM ASVCGASLAL MDAGVPIKAA VAGIAMGLVK EGDNYVVLSD
490 500 510 520 530 540
ILGDEDHLGD MDFKVAGSRD GISALQMDIK IEGITKEIMQ VALNQAKGAR LHILGVMEQA
550 560 570 580 590 600
INAPRGDISE FAPRIHTIKI NPDKIKDVIG KGGSVIRALT EETGTTIEIE DDGTVKIAAT
610 620 630 640 650 660
DGEKAKHAIR RIEEITAEIE VGRVYNGKVT RIVDFGAFVA IGGGKEGLVH ISQIADKRVE
670 680 690 700 710
KVTDYLQMGQ EVPVKVLEVD RQGRIRLSIK EATEQSQPAA APEAPAAEQG E