Q8F4P5

PR
Gene name
lysS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
KEGG Pathway
lil:LA_1995
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8F4P5

Entry ID Method Resolution Chain Position Source
AF-Q8F4P5-F1 Predicted AlphaFoldDB

No variants for Q8F4P5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8F4P5

No associated diseases with Q8F4P5

3 regional properties for Q8F4P5

Type Name Position InterPro Accession
conserved_site Translation initiation factor 3, conserved site 71 - 84 IPR019813
domain Translation initiation factor 3, N-terminal 20 - 89 IPR019814
domain Translation initiation factor 3, C-terminal 97 - 181 IPR019815

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSESNELIEQ RIQKIEELKK QGINPYPVRF FPDSKSKDIA EKFEKNPTGP ETKFKLGGRL
70 80 90 100 110 120
HSKRVMGKAS FAHLKDNSGI IQLYATKDDL GETQYSIFKS LDLGDIIGLE GYLFKTQKGE
130 140 150 160 170 180
ITLHVTSVEL LAKCIRPLPV VKEKDGVVYD AFADVEQRYR MRYVDLIVND HVRDTFITRS
190 200 210 220 230 240
KIVSEIRSFL TQEGFLEVET PMMQPIAGGA AARPFVTHHN TLDMQLFLRI APELYLKRLI
250 260 270 280 290 300
VGGMDRVFEL NRNFRNEGIS TKHNPEFTMM EAYMAFGDMS TMLDLTERLI THLAQKICGT
310 320 330 340 350 360
LKIQYGKDLI DLSPPWKRTT YVDIIKEYSG IDFSQIISLE EAKKKASELK VDVSKCQTIW
370 380 390 400 410 420
KVADEVFSEK AEPNLIQPIF ITDYPKELSP LAKSNPDKPG YVERFEPYVA GREIGNAFTE
430 440 450 460 470 480
LNDPFDQKER FEDQVKQREA GDDEAFMMDE DYIRALEYGM PPTGGLGIGI DRLVMLLTNS
490
HSIRDTILFP LMRPE