Q8F445
Gene name |
leuA1 |
Protein name |
2-isopropylmalate synthase 1 |
Names |
Alpha-IPM synthase 1, Alpha-isopropylmalate synthase 1 |
Species |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) |
KEGG Pathway |
lil:LA_2202 |
EC number |
2.3.3.13: Acyl groups converted into alkyl groups on transfer |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8F445
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8F445-F1 | Predicted | AlphaFoldDB |
No variants for Q8F445
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8F445 | |||||
No associated diseases with Q8F445
4 regional properties for Q8F445
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pyruvate carboxyltransferase | 7 - 275 | IPR000891 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 14 - 30 | IPR002034-1 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 201 - 214 | IPR002034-2 |
| domain | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 371 - 501 | IPR013709 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.3.13 | Acyl groups converted into alkyl groups on transfer |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-isopropylmalate synthase activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| leucine biosynthetic process | The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLKDYVRIF | DTTLRDGEQC | PGAAMTENEK | LEIASQLATM | KVDIIEAGFP | VSSPVQFQAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ERIARETEGP | MIAALARAMK | ADIEAASKAL | QPAKKRRIHT | FIASSPIHMK | YKLGKEPKEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKMAVEAVTL | CRQFVDDVEF | SPEDATRSEP | EFLRELCEAV | IAAGATTINI | PDTVGYTTPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYGGLFKFLL | SNVRGAEKII | FSAHCHNDLG | LATANSLAAV | QNGARQIECT | INGIGERAGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TAMEEVVMAM | RTRKDTFGIQ | TQIKTEEIAR | ASYLVKTITG | MLVQPNKAIV | GANAFAHESG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IHQDGVIKHR | ETYEIMKPET | VGLSSNRMVL | GRHSGRAGFK | DRIVKLGFSP | QVEELEAAYQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFLEIADRKK | EIYDEDIRAL | FSEEARKSTG | DRFQLEGFTV | STGTKSTPTA | GVRILIDGHV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REESATGDGP | VDAIYKAIQK | TTGMDPEVSR | LVISPVTEGQ | DAMAEASVTL | EYKGDRVVGK |
| 490 | 500 | ||||
| GSSTDIIEAC | SRAYISALNR | L |