Q8F242

PR
Gene name
purM
Protein name
Phosphoribosylformylglycinamidine cyclo-ligase
Names
AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
KEGG Pathway
lil:LA_2935
EC number
6.3.3.1: Cyclo-ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8F242

Entry ID Method Resolution Chain Position Source
AF-Q8F242-F1 Predicted AlphaFoldDB

No variants for Q8F242

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8F242

No associated diseases with Q8F242

2 regional properties for Q8F242

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 176 - 342 IPR010918
domain PurM-like, N-terminal domain 63 - 164 IPR016188

Functions

Description
EC Number 6.3.3.1 Cyclo-ligases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylamine-glycine ligase activity Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.

3 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
adenine biosynthetic process The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEKITYKNA GVDTEKGREF IQKIKRNVES THGPRVIGGL GGFAGAYDVS VLKKYKHPIL
70 80 90 100 110 120
LSGTDGVGTK IELARLLKIY NTIGIDLVAM CVNDILVCGG EPLFFLDYIA CGKLDPEKMD
130 140 150 160 170 180
QIVSGIVQGC KMSNASLLGG ETAEHPGTMK EDEFDLAGFV VGAVEKDSMI DGSTIRSGDK
190 200 210 220 230 240
ILGLESSGPH SNGFSLIRKL LLKEGKYLPT DPQQVKFLKD YALKPTRIYV SSILKLLQQV
250 260 270 280 290 300
SVKGMVHITG GGYQENVPRI LPQGTQSKFF KEKIPSGYFF EKIKKDHKIE ELELFATFNM
310 320 330 340
GIGYMVIVSE ENAELAKKIM ESSGEVVHEI GEIVSGNKEE VQFV