Q8EZT8

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
KEGG Pathway
lil:LA_3763
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EZT8

Entry ID Method Resolution Chain Position Source
AF-Q8EZT8-F1 Predicted AlphaFoldDB

No variants for Q8EZT8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EZT8

No associated diseases with Q8EZT8

5 regional properties for Q8EZT8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 45 - 56 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 18 - 563 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 611 - 756 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 816 - 880 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 564 - 703 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKQIGDRYE PKDVENKWIS LWEKKKSFAP NSNARESFSI VIPPPNVTGS LHIGHALNHT
70 80 90 100 110 120
IQDILVRIER KKGKSTLWLP GMDHAGIATQ MVVERELAKE SKKRTDFTRE EFIHKVWEWK
130 140 150 160 170 180
NHSGGMITKQ QKLLGESVDW SRERFTLDEG LSKAVFKVFK SLYDEGLIYR GERIINWCPA
190 200 210 220 230 240
SQTAISDLEV EFRETKGKLY HIKYPIHGKK DQFLVVATTR PETMLGDVAV CANPEDERYT
250 260 270 280 290 300
SLKDVVLDLP LTNRQIPLLF DSFVDKEFGS GLVKITPAHD ANDFEAGQRL GLKPLLVMNP
310 320 330 340 350 360
NGTMNENAGI YQGLDRFEAR KKVLADLEAK GLIEKIEDHI HAVGHNSRGG AVIEPYLSTQ
370 380 390 400 410 420
WFVKIKPLAD LAVQAVQSGQ VEFIPKMWEK TFFEWMNNIR DWCISRQLWW GHRIPAYHCK
430 440 450 460 470 480
KCKHFEVSET AVTVCTSCGS QEVEPDPDVL DTWFSSQLWP FSTLGWPDQT EDLKRYYPTS
490 500 510 520 530 540
VLVTGFDIIF FWVSRMIMMG MKFMQAPPFH KVLIHGLVRD KDGKKFSKSV GNVIDPLVMM
550 560 570 580 590 600
DKYGTDSFRF FLAATLPEGK DILFDESRLD GYRSFCNKIW NSSRFILMNL EESFVPIGIT
610 620 630 640 650 660
PDIEKDLEPM DQWILSRFNH CLEEYNKAHS KFHFYEMAAA IYEFIWGDFC DWYIELVKPR
670 680 690 700 710 720
AYGKVSPRSA EVAKQVLSDV LIRALGLLHP FMPFLTEEVH SVFSDQYIVT TPFPESYPVA
730 740 750 760 770 780
SDSLGVQKLN LLQEIVTKIR VMRSENGVAP DRKCKAIVKS SDNLSSSTIL ENEVSLLQLA
790 800 810 820 830 840
RLESIRIDTL YEIQKTDSVS HFTKGEIVLP LEGLIDVAKE KTRLEKELQK SELEKEKLEI
850 860 870 880
KLSNPGFLSK AAPEVVEKER DKLKTLIDKV EVLKKGIQNL AG