Q8EZ26

PR
Gene name
pheT
Protein name
Phenylalanine--tRNA ligase beta subunit
Names
Phenylalanyl-tRNA synthetase beta subunit, PheRS
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
KEGG Pathway
lil:LA_4035
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

457-586 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EZ26

Entry ID Method Resolution Chain Position Source
AF-Q8EZ26-F1 Predicted AlphaFoldDB

No variants for Q8EZ26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EZ26

No associated diseases with Q8EZ26

6 regional properties for Q8EZ26

Type Name Position InterPro Accession
domain tRNA-binding domain 39 - 147 IPR002547
domain Ferrodoxin-fold anticodon-binding domain 694 - 787 IPR005121
domain B3/B4 tRNA-binding domain 211 - 384 IPR005146
domain tRNA synthetase, B5-domain 399 - 472 IPR005147
domain Phenylalanly tRNA synthetase, tRNA-binding-domain 45 - 146 IPR033714
domain Phenylalanyl tRNA synthetase beta chain, core domain 474 - 680 IPR041616

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
phenylalanine-tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLSLDWMND FTPLKEVGLD AILKKIAISV CEIDDATEFR PELDFVKIVR IESLEKHPSA
70 80 90 100 110 120
DKLQIVQVFD GSSKSQIVTG ATNVKIGDLV PLAIPGAKLG DKEILESELR GVKSSGMLCS
130 140 150 160 170 180
EKELFLSEEG NGVWILNGLD QAEVGKTIRS FLYYDDIIFE VDNKSITHRP DLWSHFGFAR
190 200 210 220 230 240
ELASQLRLPI VFNPFESLWN FDLSVKLPKV LENQNAHSYY ASSISGVSVF PSKRKFQSRL
250 260 270 280 290 300
QKCGVRVINN VVDVSNYVML EMGQPTHFFD KKFLENQGEI SLEVSFAKKG ESFALLDETS
310 320 330 340 350 360
PALEEEVLLI RNQGKPVAIA GVMGGKESAV QNTTTEIVME SAVFMRERIR KSIRSTGIRS
370 380 390 400 410 420
DSSVRYEKGL EATTTLPVIR RALNLLKENG CSELKASEPV GFLHIPHKEV RIHTDIHFIN
430 440 450 460 470 480
AKLGVTLSQG DITDILERLH FIVSWKGEHL EVLVPKFRHN YDVTIPEDLV EEIGRTKGYD
490 500 510 520 530 540
TIQVSPLLAE VKTPIRNLNR ELERKCKTFF AIALKYHEVF NYSFQSYKEN EFSGDPKLSV
550 560 570 580 590 600
KIKNEMPEEQ SVLRNSLLPS LLKNTRTNQD RFSEIKIFEF GRVYFNLPEP ENEKKIFAFA
610 620 630 640 650 660
VSLDKKSSEP DLKLLEEDFL KIKKEVESFL ESIQIYEYTW KIQQETIFHP GANLCLVARS
670 680 690 700 710 720
GKDGLETIVG NLGYVHPAIL DSFELKKRVI YGSFEFERIV ELWNQNRKVS RFVTPSQFPE
730 740 750 760 770 780
AEIDLSILVG EKENTNVFTD LVKLERIPEL KEGWVYSQFM GGNVPEGKKS VSYRFRLVNY
790 800
ERTFTQERIK EISDQLVILA GKNGFVLR