Q8EYG2

PR
Gene name
acsA
Protein name
Acetyl-coenzyme A synthetase
Names
AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme
Species
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
KEGG Pathway
lil:LA_4254
EC number
6.2.1.1: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EYG2

Entry ID Method Resolution Chain Position Source
AF-Q8EYG2-F1 Predicted AlphaFoldDB

No variants for Q8EYG2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EYG2

No associated diseases with Q8EYG2

4 regional properties for Q8EYG2

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 96 - 533 IPR000873
conserved_site AMP-binding, conserved site 270 - 281 IPR020845
domain AMP-binding enzyme, C-terminal domain 542 - 620 IPR025110
domain Acetyl-coenzyme A synthetase, N-terminal domain 31 - 86 IPR032387

Functions

Description
EC Number 6.2.1.1 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
AMP binding Binding to AMP, adenosine monophosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
acetyl-CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPNSEEVMAK ERVVSPSAEF KKNANISLKN YKSLYKESIE NPNKFWAREA NRLIWFKKWT
70 80 90 100 110 120
KVLSHDFKNA KVEWFKGGKL NVSYNCLDRH ISTPLKNKAA LIWEGDNPTE SRVLTYYDVY
130 140 150 160 170 180
REVNRFANIL KKFGVKKGDR VLVYLPMIPE LAITILACTR IGAIHSVVFG GFSPEALQSR
190 200 210 220 230 240
IDDCKPKLVV TADGGFRGGK PIELKKNVDL ALEKSKEKVK TVIVVRRTGN ESGLTWKDGQ
250 260 270 280 290 300
DYWYHFLMND PELSAYCKPE EMDAEDPLFI LYTSGSTGKP KGVLHTTGGY LLGANLTFHY
310 320 330 340 350 360
VFDIKPEDTY WCTADIGWVT GHSYLVYGPL SNGASSVMFE GVPSYPDAGR FWDVIDKYGV
370 380 390 400 410 420
NIFYTAPTAI RALMREGLNH IQKRDLSSLR LLGSVGEPIN PEAWEWYFKN IGKGKCPIVD
430 440 450 460 470 480
TWWQTETGSI MITALPGAIP QKPGSATLPF FGVQPVLVDN DGKEITDKGE VSGNLCIKGP
490 500 510 520 530 540
WPSMMRGVYG DPKRFFETYF SQFKGYYFTG DGARRDKDGY FWITGRVDDV INVSGHRIGS
550 560 570 580 590 600
AEVESALVEN KSVAEAAVVG FPHDIKGQGI YAYVTVKEGV TTNDVLKKEL ISTVEKMIGK
610 620 630 640 650 660
IARPDVIHWA PGLPKTRSGK IMRRILRKIV SGEFEGLGDT STLADPSVVQ KLIEDKKKFH
S