Q8EJW1

PR
Gene name
prpB
Protein name
2-methylisocitrate lyase
Names
2-MIC, MICL, (2R,3S)-2-methylisocitrate lyase
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_0345
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EJW1

Entry ID Method Resolution Chain Position Source
AF-Q8EJW1-F1 Predicted AlphaFoldDB

No variants for Q8EJW1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EJW1

No associated diseases with Q8EJW1

2 regional properties for Q8EJW1

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 119 - 124 IPR018523
domain ICL/PEPM domain 9 - 251 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQSAGLRFR QALANSKPLQ IVGTTNAYFA LMAEQTGFQA LYLSGAGVAN ASYGLPDLGM
70 80 90 100 110 120
TSMNDVLIDA GRITSATQLP LLVDIDTGWG GAFNIARTIK EFEKIGVAAV HMEDQVSQKR
130 140 150 160 170 180
CGHRPNKAVV STEEMVDRIK AAVDARTDPN FVIMARTDAV AVEGLEAGIE RAKAYIAAGA
190 200 210 220 230 240
DMIFAEALTE LDQYRHFKAQ VKAPILANMT EFGQTQLFNK EELAQAGADM VLYPLGTFRA
250 260 270 280 290
ANQAALKVMQ ALMNDGHQRN VLDTMQTRAD LYKYLGYHAF EDKLDQLFSQ DK