Q8EIM0

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_0818
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

337-467 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EIM0

Entry ID Method Resolution Chain Position Source
AF-Q8EIM0-F1 Predicted AlphaFoldDB

No variants for Q8EIM0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EIM0

No associated diseases with Q8EIM0

2 regional properties for Q8EIM0

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 431 - 754 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 4 - 310 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQLNSLGFPR IGRRRELKFA LEKYWRGEST QAELHEVARE LRRTHWQWQV AAGIEQVPVG
70 80 90 100 110 120
DFAFYDQVLT LSATLNAIPD RHRGEGAIDL DTLFRVARGR APTGTDAPAS EMTKYFNTNY
130 140 150 160 170 180
HYLVPELKQD QVFSIAYEQF FDEVAEAQAL GYKAKPVLLG PVSYLYLAKT VGQDFDKLSL
190 200 210 220 230 240
LPNLLKAYAE ILARFAAQGV TWVQLEEPIL ALELTHEWQA AISESYQALK TAQVKILLTS
250 260 270 280 290 300
YYGSISHHQA LVSALPVAGL HLDLVTAPEQ LALFANALRP DQILSVGVVN GRNVWAAEVD
310 320 330 340 350 360
LIVERIGSVA RDLCSQDGSR LWIGTSCSLL HSPVDLEVET TLAPTLRQQL AFAKQKLLEL
370 380 390 400 410 420
ANVRQLLQAP ESVAAKEIVN TCLARREAKA QAADAKVIAR VAALTPADYE RVSEFTERQA
430 440 450 460 470 480
VQQRKYRLPL LPTTTIGSFP QTPAIRGLRS RWRKGELSDA QYTEQLQQVT RDTIDRQLKL
490 500 510 520 530 540
GIDVLVHGEA ERNDMVEYFG EQLEGVGFTK NGWVQSYGSR CVKPPLIYGD VSRPKAMTVD
550 560 570 580 590 600
WAVFAQSLTD KPVKGMLTGP VTILHWSFAR EDISRDTIAT QLALAIRDEV VDLQHAGIGI
610 620 630 640 650 660
IQIDEPAFRE GLPLKQSEWQ AYLDWAVNAF KLSAAGVVDE TQIHTHMCYS EFNDTIAAIA
670 680 690 700 710 720
AMDADVITIE TSRSRMELLN AFEDFEYPNE IGPGVYDIHS PNTPSVEAMV HLIEKAAQKV
730 740 750
PVRQLWVNPD CGLKTRTWDE VEPALKNMVD ATRELRRRLG