Q8EFB2

PR
Gene name
hisC
Protein name
Histidinol-phosphate aminotransferase
Names
Imidazole acetol-phosphate transaminase
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_2072
EC number
2.6.1.9: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EFB2

Entry ID Method Resolution Chain Position Source
AF-Q8EFB2-F1 Predicted AlphaFoldDB

No variants for Q8EFB2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EFB2

No associated diseases with Q8EFB2

2 regional properties for Q8EFB2

Type Name Position InterPro Accession
binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site 245 - 254 IPR001917
domain Aminotransferase, class I/classII 77 - 382 IPR004839

Functions

Description
EC Number 2.6.1.9 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQEPICQEP MSNVTVRSVP SDNSASNPLD KIVIESATLA ARLARPELLE LTPYQSARRL
70 80 90 100 110 120
GGKGDIWINA NESPFNNVAV GELDLTKLNR YPECQPPALI NAYSQYSGVV ESKIVASRGA
130 140 150 160 170 180
DEAIELLIRA FCIPGIDSIA TFGPTYGMYA ISAQTFNVGV KALSLSAEYG LPADFATAAR
190 200 210 220 230 240
GAKLVFICNP NNPTGTVIDK ARIEQAIQAL PDSIVVVDEA YIEFCPEYSV ADLLETYPNL
250 260 270 280 290 300
VVLRTLSKAF ALAGARCGFL LANEEIIEII MRVIAPYPVP LPVSEVAEQA LSPAGIARMK
310 320 330 340 350 360
TQVKELNTQG ERLAAALNLY CEQWGGAVLK PNGNYVLAEF DDVAKVAKLL TDNGIVARAY
370 380 390
KDPRLAKAIR FSFSSQVDTD RLVSLFESQK R