Q8EBS5

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_3424
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

60-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EBS5

Entry ID Method Resolution Chain Position Source
AF-Q8EBS5-F1 Predicted AlphaFoldDB

No variants for Q8EBS5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EBS5

No associated diseases with Q8EBS5

5 regional properties for Q8EBS5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 14 - 631 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 679 - 829 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 889 - 949 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 630 - 769 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKTYDPQSI EQTLYQNWEE KGYFKPHGDA SQGNYCIMIP PPNVTGSLHM GHAFQDTIMD
70 80 90 100 110 120
TLIRYQRMKG KNTLWQVGTD HAGIATQMLV ERKLEAEEGK SRHDLGRDVF MEKVWEWKAQ
130 140 150 160 170 180
SGGTITKQLR RMGASVDWDR ERFTMDEGLS KAVQEVFVRL YEDDLIYRGK RLVNWDPKLH
190 200 210 220 230 240
TAISDLEVEN KEKQGHMWHL RYPLADGELT ADGKDYLEVA TTRPETMLGD SAVAVHPDDE
250 260 270 280 290 300
RYQALIGKYI LLPIVNRRIP IVADDYVDMA FGTGCVKITP AHDFNDYEVG KRHKLPMFNV
310 320 330 340 350 360
LTLDAAIRSS AEVVNTDGTI NTSLDGSLPE RYAGLDRFKA RDAIVAEFET LGLLEKIAPH
370 380 390 400 410 420
GLKVPYGDRS GVVIEPMLTD QWYVAVAPMA KTAIEAVENG DIKFVPQQYE NMYFSWMRDI
430 440 450 460 470 480
QDWCISRQLW WGHRIPAWYD TNGKVYVGRT EAEVRAKHDI DDAIALRQDE DVLDTWFSSA
490 500 510 520 530 540
LWTFSTLGWP DNVEDLKTFH PTDVLVTGFD IIFFWVARMI MMTMHFIKDE DGKPQVPFKT
550 560 570 580 590 600
VYVTGLIRDE AGNKMSKSKG NVLDPLDMID GIDLETLVEK RTGNMMQPQL AAKIEKSTRK
610 620 630 640 650 660
EFENGIEAHG TDALRFTLAA MASTGRDINW DMKRLDGYRS FCNKLWNASR YVLMNTEGQD
670 680 690 700 710 720
CGPNSPDYQG GEMELSLADR WIIDLFNQTV KTYDEHMASY RFDLAANTLY EFTWNQFCDW
730 740 750 760 770 780
YLELTKPVLQ NGTEAQMRGT RHTLVNVLEA MQRLMHPMMP YITETIWQRV KPLTGVQGDT
790 800 810 820 830 840
IMLAPFPAFD AAKVDATAMA DLEWVKQVIV AVRNIRAELN IAPSKPLNAL LRGVSAQDKA
850 860 870 880 890 900
RIEANQAFFA TLARLESMTI LGEGETAPMS TTGLIGEMEL LIPMAGLVDV AAEMARIDKQ
910 920 930 940 950
LEKLTQEIAR IEGKLSNEGF VAKAPPAVID KERAKMADLS RDIDKLTEQK AEFAKLEA