Q8EBR9

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_3431
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

769-856 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EBR9

Entry ID Method Resolution Chain Position Source
AF-Q8EBR9-F1 Predicted AlphaFoldDB

No variants for Q8EBR9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EBR9

No associated diseases with Q8EBR9

5 regional properties for Q8EBR9

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 611 - 801 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 13 - 124 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 595 IPR007696
domain DNA mismatch repair protein MutS, connector domain 133 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 432 - 521 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPIDTDDLE KHTPMMRQYL SMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
70 80 90 100 110 120
GKSGGDPIPM AGIPYHAVEG YLAKLVQIGQ SVAICEQIGD PATSKGPVER KVVRIVTPGT
130 140 150 160 170 180
LTDEALLQER QDNLLAAVYQ GKVGFGYATL DVSSGRFVIA ELETKESLEA ELQRTNPVEI
190 200 210 220 230 240
LYSEDFGALD LLHHFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIT DARLSLQAAG
250 260 270 280 290 300
CLMQYVKDTQ RTALPHINAI TRFNQTDTIV LDAATRRNLE LTQNLSGGRD NTLAAVLDNT
310 320 330 340 350 360
ATAMGSRMLQ RWIHQPLRDH ALILARQTAV NELLETAVHE SLHEQLKALG DIERIMARLA
370 380 390 400 410 420
LRTARPRDFA RLRQALSLLP QLQLSLSQLS APHTVKLGQL LGEFPQEQQL LEHAIVDNPP
430 440 450 460 470 480
MLIRDGGVIR EGYNAELDEW RGLSEGASDY LVQLEAREKE RTGIATLKVG YNRVHGYYIE
490 500 510 520 530 540
VSRLQSNQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWDELFDLIL
550 560 570 580 590 600
PKLHELQDFA RAAAELDVLS NFAERAETLG YTSPELSSEI GVKIEAGRHP VVERVSQTPF
610 620 630 640 650 660
IANPVTLHNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPAERAT IGPIDRIFTR
670 680 690 700 710 720
IGASDDLASG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
730 740 750 760 770 780
QQVGAMTLFA THYFELTQLP ELMSGVYNVH LDAIEHEDTI AFMHAVQEGA ASKSYGLQVA
790 800 810 820 830 840
ALAGVPARVI KAAKHKLHQL ESRDHQVEGT KTPIQTLLAL PEPVENPAVS KLKAINPDNL
850
TPKQALDLLY ELKRLS