Q8EAY1

PR
Gene name
glnE
Protein name
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Names
ATP:glutamine synthetase adenylyltransferase, ATase
Species
Shewanella oneidensis (strain MR-1)
KEGG Pathway
son:SO_3760
EC number
2.7.7.42: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8EAY1

Entry ID Method Resolution Chain Position Source
AF-Q8EAY1-F1 Predicted AlphaFoldDB

No variants for Q8EAY1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8EAY1

No associated diseases with Q8EAY1

4 regional properties for Q8EAY1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 23 - 34 IPR001412
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 17 - 323 IPR020058
domain Glutamyl-tRNA synthetase 17 - 330 IPR033910
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 337 - 477 IPR045462

Functions

Description
EC Number 2.7.7.42 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
[glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)].
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVQKDSNKS LSPLITQASE RHWARLTEVW SEGLANLTAA QQQELKTVLG LSDYIANQLT
70 80 90 100 110 120
RSPEWINALF ADDLQQVERK LFDAQLREQL ASATTEDMAK RLLRRFRNYQ MVRFAWRDFL
130 140 150 160 170 180
DYASLEESLL DLSALAEALV IGARDWLYKE MCVQYGTPMD KAGNPQPLLI LGMGKLGGRE
190 200 210 220 230 240
LNFSSDIDLI FTFPEHGETV GGRRSLDNQQ FFIRMGQRLV NLLDQITVDG FVFRVDMRLR
250 260 270 280 290 300
PYGESGPLVV SFSGLEDYYQ EQGRDWERYA MVKARSLGPW NHFSDELHSL LRPFVYRRYI
310 320 330 340 350 360
DFSAIESLRK MKQLIAQEVR RRQLTDNIKL GAGGIREVEF VVQSFQLIRG GREPSLRQQS
370 380 390 400 410 420
LFGAMDTLYS LGQFEYLAVD ELKHSYLLLR RVENLLQAID DKQTQTLPNN ALDWARLCYV
430 440 450 460 470 480
LDMTNEIDLR THIEAAMAKI HRHFKATVGG EEGEEKAEHW TAQLWNVQQD DHAINLLAEQ
490 500 510 520 530 540
QIDDDKLWPL LSRWRETVTK RSIGPRGRET LDKLMPRLLD ELLNQPSPSA AFEPVSKVLE
550 560 570 580 590 600
QILTRTTYLE LLCENPGARQ QLVSLCCASP WIAVQLAKFP MLLDELIDPA HLYDTTSLDD
610 620 630 640 650 660
YPSELRQYLL RVPEDDMEQQ MEALRQFKLS QQLKIAAADV TGVLPVMQVS DHLTFLAEAI
670 680 690 700 710 720
IEQVVMQAWQ QVAVRHGVPS YLAESSDTGF AVIGYGKLGG IELGYGSDLD LVFLYEAPEN
730 740 750 760 770 780
MANSLTNGDR PIEVGHFYLK LAQRILHLFS TRTTSGELYE VDMRLRPSGA SGLMVSEIAR
790 800 810 820 830 840
FGEYQAQEAW TWEHQALVRS RFVFGDNSLA VKFSQIRACV LEQSRDKDEL KKAVREMRQK
850 860 870 880 890 900
MRDHLLKVSE GEFDLKQSPG GITDIEFIAQ YLVLANAHEY PELSIWSDNV RIFGVLAELE
910 920 930 940 950
LLPLMSAQHL TQSYCWLRDE NHRLTLQQKS GKLAYADVAA HAERILAIYQ AILE