Q8DVR7
Gene name |
dinB |
Protein name |
DNA polymerase IV |
Names |
Pol IV |
Species |
Streptococcus mutans serotype c (strain ATCC 700610 / UA159) |
KEGG Pathway |
smu:SMU_403 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8DVR7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8DVR7-F1 | Predicted | AlphaFoldDB |
No variants for Q8DVR7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8DVR7 | |||||
No associated diseases with Q8DVR7
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| SOS response | An error-prone process for repairing damaged microbial DNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLIFPLINDT | SRKIIHIDMD | AFFAAVEERD | NPKLKGKPLV | IGADPRQTGG | RGVVSTANYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AREFGIHSAM | SSKEAYERCP | QAIFIRGNHT | KYRQIGLQVR | EIFRRYTDLV | EPMSIDEAYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVTENKLNIK | SAVKIAKLIQ | RDIWEEFHLT | CSAGVSYNKF | LAKLASDYDK | PHGLTVILPQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DAEGFLATLP | IEKFYGVGKK | SVEKLHALHI | FTGKDVQQVP | EMTLIDLFGR | FGFDLYRKAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GISNSPVKND | RIRKSIGSER | TYGKLLYNDE | DIKLELSKTA | RRVADSLKKH | GRKGKIVVIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRYSDFSTLT | KRKTLDVPTQ | DFEVIERSAH | RIFDHLTENN | SGVRLLGVTV | TALEDSTREE |
| LSLTADDFKT |