Q8DTE3
Gene name |
cas9 |
Protein name |
CRISPR-associated endonuclease Cas9 |
Names |
|
Species |
Streptococcus mutans serotype c (strain ATCC 700610 / UA159) |
KEGG Pathway |
smu:SMU_1405c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8DTE3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8DTE3-F1 | Predicted | AlphaFoldDB |
No variants for Q8DTE3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8DTE3 | |||||
No associated diseases with Q8DTE3
5 regional properties for Q8DTE3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | HNH nuclease | 821 - 871 | IPR003615 |
| domain | CRISPR-associated endonuclease Cas9, PAM-interacting domain | 1081 - 1335 | IPR032237 |
| domain | CRISPR-associated endonuclease Cas9, bridge helix | 62 - 94 | IPR032239 |
| domain | CRISPR-associated endonuclease Cas9, REC lobe | 181 - 713 | IPR032240 |
| domain | Cas9-type HNH domain | 770 - 921 | IPR033114 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| metal ion binding | Binding to a metal ion. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| maintenance of CRISPR repeat elements | Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKPYSIGLD | IGTNSVGWAV | VTDDYKVPAK | KMKVLGNTDK | SHIEKNLLGA | LLFDSGNTAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRRLKRTARR | RYTRRRNRIL | YLQEIFSEEM | GKVDDSFFHR | LEDSFLVTED | KRGERHPIFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLEEEVKYHE | NFPTIYHLRQ | YLADNPEKVD | LRLVYLALAH | IIKFRGHFLI | EGKFDTRNND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQRLFQEFLA | VYDNTFENSS | LQEQNVQVEE | ILTDKISKSA | KKDRVLKLFP | NEKSNGRFAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLKLIVGNQA | DFKKHFELEE | KAPLQFSKDT | YEEELEVLLA | QIGDNYAELF | LSAKKLYDSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLSGILTVTD | VGTKAPLSAS | MIQRYNEHQM | DLAQLKQFIR | QKLSDKYNEV | FSDVSKDGYA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GYIDGKTNQE | AFYKYLKGLL | NKIEGSGYFL | DKIEREDFLR | KQRTFDNGSI | PHQIHLQEMR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIIRRQAEFY | PFLADNQDRI | EKLLTFRIPY | YVGPLARGKS | DFAWLSRKSA | DKITPWNFDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IVDKESSAEA | FINRMTNYDL | YLPNQKVLPK | HSLLYEKFTV | YNELTKVKYK | TEQGKTAFFD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ANMKQEIFDG | VFKVYRKVTK | DKLMDFLEKE | FDEFRIVDLT | GLDKENKVFN | ASYGTYHDLC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KILDKDFLDN | SKNEKILEDI | VLTLTLFEDR | EMIRKRLENY | SDLLTKEQVK | KLERRHYTGW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GRLSAELIHG | IRNKESRKTI | LDYLIDDGNS | NRNFMQLIND | DALSFKEEIA | KAQVIGETDN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LNQVVSDIAG | SPAIKKGILQ | SLKIVDELVK | IMGHQPENIV | VEMARENQFT | NQGRRNSQQR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LKGLTDSIKE | FGSQILKEHP | VENSQLQNDR | LFLYYLQNGR | DMYTGEELDI | DYLSQYDIDH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IIPQAFIKDN | SIDNRVLTSS | KENRGKSDDV | PSKDVVRKMK | SYWSKLLSAK | LITQRKFDNL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TKAERGGLTD | DDKAGFIKRQ | LVETRQITKH | VARILDERFN | TETDENNKKI | RQVKIVTLKS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NLVSNFRKEF | ELYKVREIND | YHHAHDAYLN | AVIGKALLGV | YPQLEPEFVY | GDYPHFHGHK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ENKATAKKFF | YSNIMNFFKK | DDVRTDKNGE | IIWKKDEHIS | NIKKVLSYPQ | VNIVKKVEEQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TGGFSKESIL | PKGNSDKLIP | RKTKKFYWDT | KKYGGFDSPI | VAYSILVIAD | IEKGKSKKLK |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TVKALVGVTI | MEKMTFERDP | VAFLERKGYR | NVQEENIIKL | PKYSLFKLEN | GRKRLLASAR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ELQKGNEIVL | PNHLGTLLYH | AKNIHKVDEP | KHLDYVDKHK | DEFKELLDVV | SNFSKKYTLA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EGNLEKIKEL | YAQNNGEDLK | ELASSFINLL | TFTAIGAPAT | FKFFDKNIDR | KRYTSTTEIL |
| 1330 | 1340 | ||||
| NATLIHQSIT | GLYETRIDLN | KLGGD |