Q8DRP9
Gene name |
tilS |
Protein name |
tRNA(Ile)-lysidine synthase |
Names |
tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase |
Species |
Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
KEGG Pathway |
spr:spr0010 |
EC number |
6.3.4.19: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8DRP9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8DRP9-F1 | Predicted | AlphaFoldDB |
No variants for Q8DRP9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8DRP9 | |||||
No associated diseases with Q8DRP9
9 regional properties for Q8DRP9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 423 - 646 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1210 - 1443 | IPR003439-2 |
| domain | AAA+ ATPase domain | 450 - 639 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1236 - 1418 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 82 - 350 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 860 - 1155 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 548 - 562 | IPR017871 |
| domain | CFTR regulator domain | 639 - 849 | IPR025837 |
| domain | Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 | 389 - 670 | IPR047082 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.19 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MREPDFLNHF | LKKGYFKKHA | KAVLALSGGL | DSMFLFKVLS | TYQKELEIEL | ILAHVNHKQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IESDWEEKEL | RKLAAEAELP | IYISNFSGEF | SEARARNFRY | DFFQEVMKKT | GATALVTAHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADDQVETIFM | RLIRGTRLRY | LSGIKEKQVV | GEIEIIRPFL | HFQKKDFPSI | FHFEDTSNQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NHYFRNRIRN | SYLPELEKEN | PRFRDAILGI | GNEILDYDLA | IAELSNNINV | EDLQQLFSYS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESTQRVLLQT | YLNRFPDLNL | TKAQFAEVQQ | ILKFKSQYRH | PIKNGYELIK | EYQQFQICKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPQADEKEDE | LVLHYQNQVA | YQGYLFSFGL | PLEGELIQQI | PVSRETSIHI | RHRKTGDVLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNGHRKKLRR | LFIDLKIPME | KRNSALIIEQ | FGEIVSILGI | ATNNLSKKTK | NDIMNTVLYI |
| EKIDR |