Q8DNK7

PR
Gene name
galK
Protein name
Galactokinase
Names
Galactose kinase
Species
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
KEGG Pathway
spr:spr1668
EC number
2.7.1.6: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8DNK7

Entry ID Method Resolution Chain Position Source
AF-Q8DNK7-F1 Predicted AlphaFoldDB

No variants for Q8DNK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8DNK7

No associated diseases with Q8DNK7

5 regional properties for Q8DNK7

Type Name Position InterPro Accession
conserved_site GHMP kinase, ATP-binding, conserved site 125 - 136 IPR006203
domain GHMP kinase N-terminal domain 118 - 185 IPR006204
domain GHMP kinase, C-terminal domain 290 - 370 IPR013750
domain Galactokinase, N-terminal domain 13 - 61 IPR019539
conserved_site Galactokinase, conserved site 30 - 41 IPR019741

Functions

Description
EC Number 2.7.1.6 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
galactokinase activity Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQHLTAETL RKDFLAVFGQ EVDQTFFSPG RINLIGEHTD YNGGHVFPVA ISLGTYGAAR
70 80 90 100 110 120
KRDDQVLRFY SANFEDKGII EVPLADLKFE KEHNWTNYPK GVLHFLQEAG HVIDKGFDFY
130 140 150 160 170 180
VYGNIPNGSG LSSSASLEIL TGVVAEHLFD LKLERLDLVK IGKQTENNFI GVNSGIMDQF
190 200 210 220 230 240
AIGMGADQRA IYLDTNTLEY DLVPLDLKDN VVVIMNTNKR RELADSKYNE RRAECEKAVE
250 260 270 280 290 300
ELQVALDIQT LGELDEWAVD QYSYLIKDEN RLKRARHAVL ENQRTLKAQA ALQAGDLETF
310 320 330 340 350 360
GRLMNASHVS LEHDYEVTGL ELDTLVHTAW AQEGVLGARM TGAGFSGCAI ALVQKDTVEA
370 380 390
FKEAVGKHYE EVVGYAPSFY IAEVAGGTRV LD