Q8DNF0
Gene name |
rpoB |
Protein name |
DNA-directed RNA polymerase subunit beta |
Names |
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta |
Species |
Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
KEGG Pathway |
spr:spr1777 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8DNF0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8DNF0-F1 | Predicted | AlphaFoldDB |
No variants for Q8DNF0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8DNF0 | |||||
No associated diseases with Q8DNF0
7 regional properties for Q8DNF0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | 558 - 945 | IPR007120 |
| conserved_site | RNA polymerase, beta subunit, conserved site | 795 - 807 | IPR007121 |
| domain | RNA polymerase Rpb2, domain 7 | 947 - 1021 | IPR007641 |
| domain | RNA polymerase Rpb2, domain 2 | 117 - 300 | IPR007642 |
| domain | RNA polymerase, beta subunit, protrusion | 46 - 341 | IPR007644 |
| domain | RNA polymerase Rpb2, domain 3 | 357 - 425 | IPR007645 |
| domain | DNA-directed RNA polymerase, beta subunit, external 1 domain | 435 - 500 | IPR019462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| ribonucleoside binding | Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGHDVQYGK | HRTRRSFSRI | KEVLDLPNLI | EIQTDSFKAF | LDHGLKEVFE | DVLPISNFTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TMELEFVGYE | IKEPKYTLEE | ARIHDASYSA | PIFVTFRLIN | KETGEIKTQE | VFFGDFPIMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EMGTFIINGG | ERIIVSQLVR | SPGVYFNDKV | DKNGKVGYGS | TVIPNRGAWL | ELESDSKDIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTRIDRTRKI | PFTTLVRALG | FSGDDEIFDI | FGDSELVRNT | VEKDIHKNPM | DSRTDEALKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IYERLRPGEP | KTAESSRSLL | VARFFDPRRY | DLAAVGRYKI | NKKLNVKTRL | LNQTIAEPLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DPETGEILVE | AGTIMTRSVI | ESIESHLDGD | LNKIVYIPND | AAVVTEPVVL | QKFKVVAPTD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PDRVVTIIGN | ANPDDKVRTV | TPADILAEMS | YFLNLAEGLG | RVDDIDHLGN | RRIRAVGELL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ANQVRLGLSR | MERNVRERMS | VQDNEVLTPQ | QIINIRPVTA | AVKEFFGSSQ | LSQFMDQHNP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSELSHKRRL | SALGPGGLTR | DRAGYEVRDV | HYTHYGRMCP | IETPEGPNIG | LINNLSSYGH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LNKYGFVQTP | YRKVDRETGV | VTNEIVWLTA | DEEDEYTVAQ | ANSRLNEDGT | FAEKIVMGRH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QGVNQEYPAN | IVDYMDVSPK | QVVAVATACI | PFLENDDSNR | ALMGANMQRQ | AVPLINPQAP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YVGTGMEYQA | AHDSGAAVIA | QYDGKVTYAD | ADKVEVRRED | GSLDVYHIQK | FRRSNSGTAY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NQRTLVKVGD | VVEKGDFIAD | GPSMENGEMA | LGQNPIVAYM | TWEGYNFEDA | VIMSERLVKD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DVYTSVHLEE | YESETRDTKL | GPEEITREIP | NVGEDALKDL | DEMGIIRIGA | EVKEGDILVG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KVTPKGEKDL | SAEERLLHAI | FGDKSREVRD | TSLRVPHGAD | GVVRDVKIFT | RVNGDELQSG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VNMLVRVYIA | QKRKIKVGDK | MAGRHGNKGV | VSRIVPVEDM | PYLPDGTPVD | IMLNPLGVPS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RMNIGQVMEL | HLGMAARTLG | IHIATPVFDG | ASSEDLWSTV | KEAGMDSDAK | TILYDGRTGE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| PFDNRVSVGV | MYMIKLHHMV | DDKLHARSVG | PYSTVTQQPL | GGKAQFGGQR | FGEMEVWALE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AYGASNVLQE | ILTYKSDDIN | GRLKAYEAIT | KGKPIPKPGV | PESFRVLVKE | LQSLGLDMRV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LDEDDQEVEL | RDLDEGMDED | VIHVDDLEKA | REKAAQEAKA | AFEAEEAEKA | TKAEATEEAA |
| EQE |