Q8DC49

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Vibrio vulnificus (strain CMCP6)
KEGG Pathway
vvu:VV1_1593
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8DC49

Entry ID Method Resolution Chain Position Source
AF-Q8DC49-F1 Predicted AlphaFoldDB

No variants for Q8DC49

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8DC49

No associated diseases with Q8DC49

4 regional properties for Q8DC49

Type Name Position InterPro Accession
domain DHHA1 domain 722 - 856 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 652 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 7 - 555 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYMSTDEVRN AFLKFFESKG HQIVDSSSLV PHNDPTLLFT NAGMNQFKDC FLGAEKRAYT
70 80 90 100 110 120
RATTAQRCVR AGGKHNDLEN VGFTARHHTF FEMLGNFSFG DYFKEDAIAF AWEFLTETLK
130 140 150 160 170 180
LPKDRLLVTV YETDDEAFDI WNQKVGVPAD RIIRIGDKKG GKQYESDNFW TMGDTGPCGP
190 200 210 220 230 240
CTEIFYDHGE HIWGGRPGTP EEDGDRFIEI WNNVFMQFNR HADGTMEPLP KPSVDTGMGI
250 260 270 280 290 300
ERISAIMQGV HSNYEIDVFQ KLIKATAEIV GCEDLSNQSL RVIADHIRSC SFLIADGVMP
310 320 330 340 350 360
SNEGRGYVLR RIIRRAVRHG NKLGAQGVFF HKLVGVLAEA MGSAADELKK QQAVVEKVLR
370 380 390 400 410 420
IEEENFGRTL ERGMVILNEA LDALEGKELD GETVFKLYDT YGFPADLTND VAREREFTID
430 440 450 460 470 480
EAGFEKAMEE QRQRAREAGQ FGTDYNAKIK VDAQSEFCGY TSTQERSDVV ALFVEGEETA
490 500 510 520 530 540
TLSAGDKAIV ILQETPFYAE SGGQCGDSGV LKTESGLFQV EDTQKLGNAI AHHGVLVEGV
550 560 570 580 590 600
LAKGDQVTAI VDAERRAAIS LNHSATHLLH AALRQVLGEH VAQKGSLVKA ENLRFDFSHL
610 620 630 640 650 660
EAVTAAELKE VERLVNAQIR RNHAIETNIM DIESAKQKGA MALFGEKYDD EVRVLSMGDF
670 680 690 700 710 720
STELCGGIHA SNTGDIGLFK ITSEGGIAAG IRRIEAVTGE AALEAIDAQA RKFEEKLQDA
730 740 750 760 770 780
ANKAKSLEKE IQQLKDKLAS QASANLIDQV KEIAGVKVLV AKLDGADNKA LRGMVDELKN
790 800 810 820 830 840
QMGSGIIMLG NVADDKVGLI AGVTQDLTSK VKAGELVNMV AQQVGGKGGG RPDMAQAGGT
850
DSSALPSALA SVDAWIAERL