Q8D8C0

PR
Gene name
rluB (VV1_3060)
Protein name
Ribosomal large subunit pseudouridine synthase B
Names
23S rRNA pseudouridine(2605) synthase, rRNA pseudouridylate synthase B, rRNA-uridine isomerase B
Species
Vibrio vulnificus (strain CMCP6)
KEGG Pathway
vvu:VV1_3060
EC number
5.4.99.22: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

211-320 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8D8C0

Entry ID Method Resolution Chain Position Source
AF-Q8D8C0-F1 Predicted AlphaFoldDB

No variants for Q8D8C0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8D8C0

No associated diseases with Q8D8C0

3 regional properties for Q8D8C0

Type Name Position InterPro Accession
domain RNA-binding S4 domain 3 - 73 IPR002942
domain Pseudouridine synthase, RsuA/RluA-like 68 - 201 IPR006145
conserved_site Pseudouridine synthase, RsuA/RluB/E/F, conserved site 106 - 120 IPR018496

Functions

Description
EC Number 5.4.99.22 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA pseudouridine synthase activity Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNEKLQKVLA RAGHGSRREL EALIKSGRVS VNGIVAKLGE RLEDEQAVVR IDGHVVSVKA
70 80 90 100 110 120
QEEVICRVLA YYKPEGELCT RHDPEGRRTV FDRLPKIRGS RWISVGRLDA NTSGLLLFTT
130 140 150 160 170 180
DGELANRLMH PSRQVEREYL VRVFGEVNEH KVRNLVNGVE LDDGLARFED VVYTGGEGMN
190 200 210 220 230 240
HTFYVVINEG RNREVRRLWE SQDCTVSRLK RVRYGDIYLD KKLPRGGWME LELKDVNYLR
250 260 270 280 290 300
ELVELRPEKE TMIELNNSSR KRDRARSQKI RRAVKRHEER VSTPKGRSNN AARRKPSKAD
310
GQTNKTNSRN QAGSRSKPQR