Q8D4Z3

PR
Gene name
murP (VV2_1142)
Protein name
PTS system N-acetylmuramic acid-specific EIIBC component
Names
EIIBC-MurNAc
Species
Vibrio vulnificus (strain CMCP6)
KEGG Pathway
vvu:VV2_1142
EC number
2.7.1.192: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8D4Z3

Entry ID Method Resolution Chain Position Source
AF-Q8D4Z3-F1 Predicted AlphaFoldDB

No variants for Q8D4Z3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8D4Z3

No associated diseases with Q8D4Z3

3 regional properties for Q8D4Z3

Type Name Position InterPro Accession
domain DNA mismatch repair protein, S5 domain 2-like 212 - 329 IPR013507
conserved_site DNA mismatch repair, conserved site 93 - 99 IPR014762
domain MutL, C-terminal, dimerisation 414 - 555 IPR014790

Functions

Description
EC Number 2.7.1.192 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.

2 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKITQTMIS QLLAAVGGSS NVSKCGNCMT RLRLTLANNG VADQAVIKQI PGVMGVVESD
70 80 90 100 110 120
EQFQIILGPG KAQQAAELMN KLIESVINGD VQEQAIASDT NDLSSVAAEQ KKQMKSKQTS
130 140 150 160 170 180
AVQRFLSKFA TIFTPLIPGF IAAGLLLGFA TLLEQMFVLE QTPSQFMLDL IAYMKVFGKG
190 200 210 220 230 240
LFAFLSILIG YNAQQAFGGS GVNGAILASL FVLGYNPDAT SGIYSGMSEF FGYTIDPRGN
250 260 270 280 290 300
IIGVLLAAII GAQVERKVRE YMPDDLDMIL TSVVTLLIMG VITFVVIMPI GGELFKGMSW
310 320 330 340 350 360
LFLNLNDNPL GAAILAGLFL ISVVFGIHQG FVPVYFALME AQGFNSLFPI LAMAGGGQVG
370 380 390 400 410 420
ASLALYFKAK KDAVLRTQVK GAIIPGILGI GEPLIYGVTL PRVKPFVTAC IGGAAGGFFI
430 440 450 460 470 480
GLVSYLGLPV GLNTVFGPSG IVAIPLMTSH SGIFAGMAVF VVGLLISYVV GFLATYFFGS
KDVDLS