Q8D2I8

PR
Gene name
clsA
Protein name
Cardiolipin synthase A
Names
CL synthase
Species
Wigglesworthia glossinidia brevipalpis
KEGG Pathway
wbr:cls
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8D2I8

Entry ID Method Resolution Chain Position Source
AF-Q8D2I8-F1 Predicted AlphaFoldDB

No variants for Q8D2I8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8D2I8

No associated diseases with Q8D2I8

5 regional properties for Q8D2I8

Type Name Position InterPro Accession
domain Phospholipase D/Transphosphatidylase 227 - 254 IPR001736-1
domain Phospholipase D/Transphosphatidylase 408 - 435 IPR001736-2
domain Phospholipase D-like domain 143 - 285 IPR025202-1
domain Phospholipase D-like domain 336 - 457 IPR025202-2
domain Cardiolipin synthase N-terminal 32 - 67 IPR027379

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.

1 GO annotations of biological process

Name Definition
cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLINFFSSIE VLFVIIKWIL LLGYWWLITE VTIRILFKRR TVPSAMAWLL IIYVVPFIGA
70 80 90 100 110 120
IIYLLLGELN LEKKRIKRSK IIWISALKKI KKLKNYKEIF TTKNSHIARS LFRLCKHRQG
130 140 150 160 170 180
IGGVKSEKIN ILNDPDNVMQ SVINDINLAK ISIEMIFYIW HPGGWTNYVV EVLIKAANRG
190 200 210 220 230 240
VKCRLILDSA GSKNFLKSIQ VKIMRKSGIK IVEALNLNIL QIFLRRMDLR QHRKMILIDN
250 260 270 280 290 300
YIGYTGSMNM IDPKFFKKNR KIGEWIDIMI RMEGPVASAM RIIFSCDWEI ETGENIFYAP
310 320 330 340 350 360
YDTKKCNIIK KDNNYKTQVI PSGPGVSEGV IHQVLLTAIY SAKKILIMTT PYLVPSDDIL
370 380 390 400 410 420
HAICTASQRG VSVYIIIPKF IDSILVKWAS RSFFSELLHA GVLIYQFEGG LLHTKSILVD
430 440 450 460 470 480
DQLSLVGTVN LDMRSLWLNF EITLMVDNRN FGKKLKKIQT NYMSLSKVLH LKEWSKRPYW
490
KRIIERFFYF FSPLL