Q8CP23

PR
Gene name
dnaG
Protein name
DNA primase
Names
Species
Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
KEGG Pathway
sep:SE_1249
EC number
2.7.7.101: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CP23

Entry ID Method Resolution Chain Position Source
AF-Q8CP23-F1 Predicted AlphaFoldDB

No variants for Q8CP23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CP23

No associated diseases with Q8CP23

6 regional properties for Q8CP23

Type Name Position InterPro Accession
domain Zinc finger, CHC2-type 4 - 97 IPR002694
domain TOPRIM domain 260 - 341 IPR006171
domain DNA primase, DnaG 2 - 416 IPR006295
domain DNA helicase, DnaB-like, N-terminal 459 - 556 IPR007693
domain DNA primase, catalytic core, N-terminal 127 - 253 IPR013264
domain Bacterial DnaG primase, TOPRIM domain 260 - 338 IPR034151

Functions

Description
EC Number 2.7.7.101 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.
primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRIDQSVIDE IKNKTDILDL VSEYVKLEKR GRNYIGLCPF HDEKTPSFTV SEDKQICHCF
70 80 90 100 110 120
GCKKGGNVFQ FTQEIKDVSF VEAVKDLGER VNIQVDIGQN QTNSSTKIAS DELKMIEMHE
130 140 150 160 170 180
LIKDYYHYAL MKTVEGEEAL NYLHERGFTD DLIKEREIGY APDNSHFCHD FLEKKGYDIE
190 200 210 220 230 240
LAFEAGLLSR NEENFTYFDR FRNRIMFPLK NGQGRIVGYS GRTYTDQEPK YLNSPETPIF
250 260 270 280 290 300
QKRRILYNLN KARKFIRKQD EIILLEGFMD VIKSDYAGLK QVVASMGTQL SQEHITFLQK
310 320 330 340 350 360
LTQNVTLMFD GDYAGKEATL KTGQALLNQG LNVYVVQLPS GMDPDDYIRK YDNEQFLKFV
370 380 390 400 410 420
QQDKQSFVLF KVKMYQNEIN HNDLAYEKHF KETVRDLSLV NSGIIRNKLI QNIADIFKVN
430 440 450 460 470 480
PETIQYELDA TYQHQMSSNT YPTFQDEPSK QQLILGRLTK NEKAERALIK HLTKDKDTFL
490 500 510 520 530 540
NYYQKIVPED FTNSYLKRIF SYLYDYYSKN DYYTISDMMQ YIESNELREV LIELDQYHLN
550 560 570 580 590
DEPYENEIED YIQIIKNNNN EDSLESLNYK LREASRIGDS ELQKYYLQLI VNKNKNRM