Q8CNX0

PR
Gene name
dnaE (SE_1378)
Protein name
DNA polymerase III subunit alpha
Names
Species
Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
KEGG Pathway
sep:SE_1378
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CNX0

Entry ID Method Resolution Chain Position Source
AF-Q8CNX0-F1 Predicted AlphaFoldDB

No variants for Q8CNX0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CNX0

No associated diseases with Q8CNX0

6 regional properties for Q8CNX0

Type Name Position InterPro Accession
domain Zinc finger, CHC2-type 4 - 97 IPR002694
domain TOPRIM domain 260 - 341 IPR006171
domain DNA primase, DnaG 2 - 416 IPR006295
domain DNA helicase, DnaB-like, N-terminal 459 - 556 IPR007693
domain DNA primase, catalytic core, N-terminal 127 - 253 IPR013264
domain Bacterial DnaG primase, TOPRIM domain 260 - 338 IPR034151

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVAHLNIHTS FDLLDSSLRI DALIDKAKKE GYRALAITDT NVLYGYPKFY DACIAAHIHP
70 80 90 100 110 120
IFGMTIYLTD GLYTIETVVL AKNNQGLKSL YQISSAIMMR NKEEVPIEWL KRYDEHLIII
130 140 150 160 170 180
FKEAELSHKQ IIDAFEGKKE LYLNHNSNNT LTGKRVWMQS ARYLNEDDAE TIPALHAIRD
190 200 210 220 230 240
NTKLDLIHEK ETLDEHFPSI EELQTLNLSE DMITNANEIE ELCQAEIAYH QSLLPQFVTP
250 260 270 280 290 300
NGETSKDYLW TILIHRLREW ELNDKTYFNR LKHEYKIITD MGFEDYFLIV SDLIHFAKTH
310 320 330 340 350 360
EVMVGPGRGS SAGSLVSYLL GITTIDPLKY NLLFERFLNP ERVTMPDIDI DFEDTRREKV
370 380 390 400 410 420
IKYVQDKYGE HHVSGIVTFG HLLARAVARD VGRIMGFDET SLNEISKLIP HKLGITLEEA
430 440 450 460 470 480
YQKPEFKAFV HRNHRNERWF EVSKKLEGLP RHTSTHAAGI IINDQPLFKF APLTTGDTGL
490 500 510 520 530 540
LTQWTMTEAE RIGLLKIDFL GLRNLSIIHQ IILQVKKDLN INIDIEAIPY DDKKVFDLLS
550 560 570 580 590 600
NGDTTGIFQL ESDGVRSVLK RLQPEHFEDI VAVTSLYRPG PMEEIPTYIT RRHNPNQVAY
610 620 630 640 650 660
LHPDLEPILK NTYGVIIYQE QIMLIASQVA GFSYGEADIL RRAMSKKNRA ILESERQHFI
670 680 690 700 710 720
DGAKNNGYGE QISKQIFDLI LKFADYGFPR AHAVSYSKIA YIMSYLKVHY PHYFYANILS
730 740 750 760 770 780
NVIGSEKKTA AMIDEAKHQR ISILPPNINQ SHWYYKASNK GIYLSLGTIK GIGYQSVKLI
790 800 810 820 830 840
IDERQQNGPY RDFFDFSRRI PKRVKNRKLL ESLILVGAFD TFGKTRATLL QAIDQVLDLN
850 860 870 880 890 900
SDVEQDEMLF DLLTPKQSYE EKEELPDQLL SDYEKEYLGF YISKHPVEKK FEKKQYLGIF
910 920 930 940 950 960
QLSNGSHYQP ILVQFDHIKQ IRTKNGQNMA FVTMNDGRTM MDGVIFPDKF KKFETSISKE
970 980 990 1000 1010 1020
QMYIVLGKFE KRNQQMQLII NQLFEVEAYE QTKLSNSKKV ILRNVTHLEP QFEHSKVESN
1030 1040 1050 1060
EQHALNIYGF DESANKMTML GQIERQRQNF DLLIQTYSPA DIRFI