Q8CIC2

PR
Gene name
Nup42 (Nupl2)
Protein name
Nucleoporin NUP42
Names
NLP-1, Nucleoporin-like protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:231042
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CIC2

Entry ID Method Resolution Chain Position Source
AF-Q8CIC2-F1 Predicted AlphaFoldDB

No variants for Q8CIC2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CIC2

No associated diseases with Q8CIC2

1 regional properties for Q8CIC2

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 1 - 25 IPR000571

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Excluded from the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.

3 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15504 NUP42 Nucleoporin NUP42 Homo sapiens (Human) PR
10 20 30 40 50 60
MTICQFFLQG RCRFGDRCWN EHPGARGAGG ARQPPPQQQP PSGNNRRGWN ASSQRYSNVI
70 80 90 100 110 120
QPSSFPKSTP WGGSRDQDKP PFGSFDSGAS TSRGFGSSQN PFASPLSDEQ KDEKKLLEGI
130 140 150 160 170 180
VKDVEVWESS GQWMFSVYSP VRKKPNISGF TDISPEELRL EYHNFLTSNN LQSYLNSVQQ
190 200 210 220 230 240
LVSQWRNRIN ELKNLTMSTK GALLSDVKDG VSQAVPAFGF GSKQAGSFGS PGFPVNNSSS
250 260 270 280 290 300
STVQNFSFKT SPGLATPPSG STSVFGSHPA FGAGPSAGSS ISSSTPAFGL GKPEATSAAS
310 320 330 340 350 360
FSFKSPEASS FASPGFSGFP ASMAASPSGS TTAPPLRSGS SVVGFGSPSP HSQAVFAKPS
370 380 390 400 410
TDVFGGSGIS TSVLASGAAD NALFTPRDQL MKEELEQFQS QRFTLGKIPL KPPPVELLTV