Q8CHR9

PR
Gene name
Pih1d2
Protein name
PIH1 domain-containing protein 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72614
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

164-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CHR9

Entry ID Method Resolution Chain Position Source
AF-Q8CHR9-F1 Predicted AlphaFoldDB

18 variants for Q8CHR9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs213471349 17 N>S No EVA
rs3389051458 66 L>F No EVA
rs228989571 80 Q>P No EVA
rs248913128 84 R>H No EVA
rs233044995 88 V>I No EVA
rs266041298 127 Q>H No EVA
rs241032039 146 H>R No EVA
rs3389010981 159 I>F No EVA
rs258978547 167 M>T No EVA
rs226476333 171 T>S No EVA
rs228112696 178 A>T No EVA
rs48262782 212 A>V No EVA
rs3389041447 234 A>P No EVA
rs251001106 239 V>I No EVA
rs213534573 243 R>Q No EVA
rs3389031623 304 N>Y No EVA
rs32747743 307 A>V No EVA
rs3389049673 313 P>A No EVA

No associated diseases with Q8CHR9

No regional properties for Q8CHR9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8CHR9

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chaperone complex A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
R2TP complex A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

1 GO annotations of molecular function

Name Definition
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
box C/D snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVSSKGLLT HISQFWNMLD DLAENDPERY RNFIQQELKD GKQLCVNPEP QLCIQTKILK
70 80 90 100 110 120
PNEKVLFINL CQWERIPAPQ SATRPVPVSV GRPEDSAEAS DAYTIIDVAY NPGVLQAAEK
130 140 150 160 170 180
DQGIKDQLIR MAMLCIEERL QFTLAHSYHL TSFRLKGSIQ RMKESLMGIK TDFPDLKAMT
190 200 210 220 230 240
RTENTLARIR SSTVSEPNHL PEVLLTKKQA SAKGRCLIEE ISSSEIQVEV KKPAYELKVV
250 260 270 280 290 300
KDRNEKPLKI ELKVELPGIK SVSLCELSVS EVDILIEVSE MYRLCLNLPE SINTEMTTAK
310
FVKNKSALII TMPLA