Q8CGZ9
Gene name |
Prl7b1 (Prlpn) |
Protein name |
Prolactin-7B1 |
Names |
Placental prolactin-like protein N, PLP-N, PRL-like protein N |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75596 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CGZ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CGZ9-F1 | Predicted | AlphaFoldDB |
9 variants for Q8CGZ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389278106 | 17 | L>V | No | EVA | |
| rs212201546 | 18 | M>V | No | EVA | |
| rs3389234333 | 54 | L>M | No | EVA | |
| rs228592981 | 60 | S>G | No | EVA | |
| rs233759617 | 107 | S>T | No | EVA | |
| rs238415091 | 124 | N>H | No | EVA | |
| rs217831675 | 135 | N>K | No | EVA | |
| rs228607353 | 150 | A>V | No | EVA | |
| rs240576460 | 218 | F>I | No | EVA |
No associated diseases with Q8CGZ9
1 regional properties for Q8CGZ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Somatotropin hormone, conserved site | 100 - 133 | IPR018116 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
| prolactin receptor binding | Binding to a prolactin receptor. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| mammary gland development | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of lactation | Any process that activates or increases the frequency, rate or extent of lactation. |
| positive regulation of receptor signaling pathway via JAK-STAT | Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. |
| response to nutrient levels | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNTSLTQLCF | WALQILLMSN | LLLWEDVVSV | PTIGSGSGVS | EMLTEDLFDD | AIILSQHINS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAIETRRIFL | SNNFSSDMFI | TFTLQFNRHD | EFVVNGLNSC | HTLPLKSPKT | EKEAKRISLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFMNMILSIL | RAWDNPLHHM | ETELKSMPGA | PFAILARVKD | IEVKNKILLD | RIMKIAKKVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YGFEENEVYP | AWSELASLQS | ANEESRFFAL | YKLSYCLFVD | TDKVEHYLKH | LKCRYFDGYM |
| 250 | |||||
| CQDSVNQINL | L |