Q8CGZ0

PR
Gene name
Cherp
Protein name
Calcium homeostasis endoplasmic reticulum protein
Names
SR-related CTD-associated factor 6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27967
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

731-851 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CGZ0

Entry ID Method Resolution Chain Position Source
AF-Q8CGZ0-F1 Predicted AlphaFoldDB

No variants for Q8CGZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CGZ0

No associated diseases with Q8CGZ0

12 regional properties for Q8CGZ0

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 43 - 75 IPR003107-1
repeat HAT (Half-A-TPR) repeat 77 - 109 IPR003107-2
repeat HAT (Half-A-TPR) repeat 111 - 143 IPR003107-3
repeat HAT (Half-A-TPR) repeat 145 - 176 IPR003107-4
repeat HAT (Half-A-TPR) repeat 178 - 209 IPR003107-5
repeat HAT (Half-A-TPR) repeat 253 - 285 IPR003107-6
repeat HAT (Half-A-TPR) repeat 295 - 327 IPR003107-7
repeat HAT (Half-A-TPR) repeat 374 - 410 IPR003107-8
repeat HAT (Half-A-TPR) repeat 412 - 443 IPR003107-9
repeat HAT (Half-A-TPR) repeat 445 - 477 IPR003107-10
repeat HAT (Half-A-TPR) repeat 518 - 550 IPR003107-11
repeat HAT (Half-A-TPR) repeat 584 - 622 IPR003107-12

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Endoplasmic reticulum
  • Distributed throughout the cytoplasm and also localizes to the perinuclear region
  • Colocalizes with ITPR1 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
sarcoplasmic reticulum membrane The lipid bilayer surrounding the sarcoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

5 GO annotations of biological process

Name Definition
cellular calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
positive regulation of calcineurin-NFAT signaling cascade Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein Homo sapiens (Human) PR
10 20 30 40 50 60
MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG EFYSYYKCKL
70 80 90 100 110 120
ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ GTPSMDELIQ QSQWSLQQQE
130 140 150 160 170 180
QHLLALRQEQ VTTAVAHAVE QQMQKLLEET QLDMSEFDNL LQPIIDTCTK DAISAGKNWM
190 200 210 220 230 240
FSNAKSPPHC ELMAGHLRNR ITADGAHFEL RLHLIYLIND VLHHCQRKQA RELLAALQKV
250 260 270 280 290 300
VVPIYCTSFL AVEEDKQQKI ARLLQLWEKN GYFDDSIIQQ LQSPALGLGQ YQATLINEYS
310 320 330 340 350 360
SVVQPVQLAF QQQIQSLKTQ HEEFVSSLAQ QQQQQQQQQQ QQPQPQPQPQ IQLPQMEADV
370 380 390 400 410 420
KATPPPPAPP PASAPAPTIP PTTQPDDNKP PIQMPGSSEY DTSAGVQDPA AAGPRGPGPH
430 440 450 460 470 480
EQIPPNKPPW FDQPHPVAPW GQQQPPEQPP YPHHQGGPPH CPPWNNSHEG MWGEQRGDPG
490 500 510 520 530 540
WNGQRDAPWN NQPDPNWNNQ FEGPWNNQHE PPPWGGAQRE PPFRMQRPPH FRGPFPPHQQ
550 560 570 580 590 600
HPQFNQPPHP HNFNRFPPRF MQDDFPPRHP FERPPYPHRF DYPQGDFPAD MGPPHHHPGH
610 620 630 640 650 660
RMPHPGINEH PPWAGPQHPD FGPPPHGFNG QPPHMRRQGP PHINHDDPSL VPNVPYFDLP
670 680 690 700 710 720
AGLMAPLVKL EDHEYKPLDP KDIRLPPPMP PSERLLAAVE AFYSPPSHDR PRNSEGWEQN
730 740 750 760 770 780
GLYEFFRAKM RARRRKGQEK RNSGPSRSRS RSKSRGRSSS RSSSRSSKSS RSSSRSHSRS
790 800 810 820 830 840
RSRSSSRSRS RSRSRSRSSR SRSRSRSRSR SKSYSPGRRR RSRSRSPTPP SAAGLGSNSA
850 860 870 880 890 900
PPIPDSRLGE ENKGHQMLVK MGWSGSGGLG AKEQGIQDPI KGGDVRDKWD QYKGVGVALD
910 920 930
DPYENYRRNK SYSFIARMKA RDEFSTFGTR KEEKED