Q8CGR7

PR
Gene name
Upp2
Protein name
Uridine phosphorylase 2
Names
UPase 2, UrdPase 2, Liver-specific uridine phosphorylase, L-UrdPase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76654
EC number
2.4.2.3: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CGR7

Entry ID Method Resolution Chain Position Source
AF-Q8CGR7-F1 Predicted AlphaFoldDB

18 variants for Q8CGR7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388556173 10 R>K No EVA
rs27907017 12 M>I No EVA
rs260358219 12 M>T No EVA
rs27906979 26 Y>S No EVA
rs3388547053 31 Y>F No EVA
rs246820048 83 R>Q No EVA
rs3388550408 109 V>M No EVA
rs27906909 136 H>R No EVA
rs3388550470 149 G>V No EVA
rs3388556098 155 P>L No EVA
rs27906881 158 V>I No EVA
rs3388556079 179 D>E No EVA
rs3388556897 234 S>L No EVA
rs3388544553 234 S>T No EVA
rs3391655927 247 R>G No EVA
rs3388544471 277 T>K No EVA
rs3388556082 299 Q>L No EVA
rs3388556102 311 K>N No EVA

No associated diseases with Q8CGR7

2 regional properties for Q8CGR7

Type Name Position InterPro Accession
domain Nucleoside phosphorylase domain 60 - 309 IPR000845
conserved_site Nucleoside phosphorylase, conserved site 113 - 128 IPR018016

Functions

Description
EC Number 2.4.2.3 Pentosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
type III intermediate filament A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.

3 GO annotations of molecular function

Name Definition
deoxyuridine phosphorylase activity Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate.
identical protein binding Binding to an identical protein or proteins.
uridine phosphorylase activity Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

5 GO annotations of biological process

Name Definition
CMP catabolic process The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate.
dCMP catabolic process The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate.
UMP catabolic process The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.
UMP salvage Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.
uridine catabolic process The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95045 UPP2 Uridine phosphorylase 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MASILPASNR SMRPDKNTYE RKRSVYVKNP YLEGMDEDIL YHLDLGTKTH NLPAMFGDVK
70 80 90 100 110 120
FVCVGGSPNR MKAFAQFMHK ELRLEGDGED IEDICAGTDR YCMFKTGPVL SVSHGMGIPS
130 140 150 160 170 180
ISIMLHELIK LLHHAHCCDV TIIRIGTSGG IGIAPGSVVI TDTAVDSFFK PRFEQVILDN
190 200 210 220 230 240
VVTRSTELDK ELANDLFNCS REIPNVPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKKLD
250 260 270 280 290 300
YLKRAYRAGV RNIEMESTVF AAMCGLCGLR AAVVCVTLLD RLESDQINLS HDVLVEYQQR
310
PQLLISNFIK KQLGLCDQMS