Q8CGN4
PR
Gene name |
Bcor (Kiaa1575) |
Protein name |
BCL-6 corepressor |
Names |
BCoR |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71458 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CGN4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CGN4-F1 | Predicted | AlphaFoldDB |
115 variants for Q8CGN4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389547830 | 3 | S>F | No | EVA | |
| rs3389500841 | 15 | M>I | No | EVA | |
| rs3389547947 | 17 | S>G | No | EVA | |
| rs3389460979 | 46 | R>G | No | EVA | |
| rs220410095 | 50 | P>S | No | EVA | |
| rs261514536 | 52 | S>N | No | EVA | |
| rs231322929 | 54 | S>N | No | EVA | |
| rs3389508950 | 55 | V>M | No | EVA | |
| rs3389554027 | 58 | T>I | No | EVA | |
| rs3389547944 | 92 | G>C | No | EVA | |
| rs3389553018 | 92 | G>D | No | EVA | |
| rs3389552999 | 96 | L>V | No | EVA | |
| rs3389565292 | 106 | P>L | No | EVA | |
| rs3389508790 | 144 | G>D | No | EVA | |
| rs3413000873 | 182 | N>K | No | EVA | |
| rs3389531502 | 190 | P>L | No | EVA | |
| rs3389562663 | 232 | P>S | No | EVA | |
| rs3409414637 | 234 | Y>* | No | EVA | |
| rs3389460927 | 234 | Y>* | No | EVA | |
| rs3389547990 | 257 | I>T | No | EVA | |
| rs3410117899 | 289 | W>R | No | EVA | |
| rs3409861510 | 295 | P>R | No | EVA | |
| rs3407543732 | 295 | P>S | No | EVA | |
| rs3409646313 | 298 | P>L | No | EVA | |
| rs3409743779 | 299 | V>L | No | EVA | |
| rs3409743768 | 300 | D>G | No | EVA | |
| rs3409698974 | 302 | H>Q | No | EVA | |
| rs3409199716 | 303 | S>G | No | EVA | |
| rs3409646251 | 304 | Y>* | No | EVA | |
| rs3409614707 | 306 | H>P | No | EVA | |
| rs232479516 | 350 | A>T | No | EVA | |
| rs3389568034 | 353 | T>I | No | EVA | |
| rs3389519344 | 402 | C>Y | No | EVA | |
| rs3389460995 | 425 | P>A | No | EVA | |
| rs3389565320 | 464 | T>S | No | EVA | |
| rs3389519408 | 474 | G>D | No | EVA | |
| rs3389562697 | 478 | S>P | No | EVA | |
| rs3389553016 | 478 | S>Y | No | EVA | |
| rs3389546941 | 511 | V>S | No | EVA | |
| rs3389565330 | 512 | P>S | No | EVA | |
| rs3389562683 | 514 | P>S | No | EVA | |
| rs3389508980 | 515 | S>I | No | EVA | |
| rs3389548006 | 542 | S>F | No | EVA | |
| rs3408510418 | 553 | V>L | No | EVA | |
| rs228938633 | 554 | V>I | No | EVA | |
| rs3408431652 | 564 | S>WAS* | No | EVA | |
| rs3409614743 | 598 | Q>* | No | EVA | |
| rs3389557610 | 651 | A>E | No | EVA | |
| rs3409861547 | 726 | V>G | No | EVA | |
| rs3409698981 | 733 | H>P | No | EVA | |
| rs3408431591 | 734 | T>R | No | EVA | |
| rs3407543757 | 748 | S>Y | No | EVA | |
| rs3389460945 | 754 | A>S | No | EVA | |
| rs3409511933 | 797 | T>S | No | EVA | |
| rs221151863 | 818 | T>A | No | EVA | |
| rs249994696 | 842 | S>T | No | EVA | |
| rs232350030 | 847 | I>M | No | EVA | |
| rs215571669 | 850 | R>C | No | EVA | |
| rs246303562 | 854 | I>T | No | EVA | |
| rs3409646241 | 942 | P>L | No | EVA | |
| rs229466741 | 943 | A>S | No | EVA | |
| rs3408510425 | 944 | Y>H | No | EVA | |
| rs3409698842 | 1037 | E>A | No | EVA | |
| rs3408510358 | 1043 | T>N | No | EVA | |
| rs3409743823 | 1050 | K>T | No | EVA | |
| rs1132683426 | 1078 | D>G | No | EVA | |
| rs259109601 | 1082 | S>T | No | EVA | |
| rs3408510349 | 1089 | T>P | No | EVA | |
| rs3389553009 | 1104 | L>H | No | EVA | |
| rs252604352 | 1121 | S>N | No | EVA | |
| rs3389554038 | 1133 | T>A | No | EVA | |
| rs241414395 | 1135 | R>P | No | EVA | |
| rs3389553359 | 1178 | M>V | No | EVA | |
| rs3389553025 | 1180 | N>Y | No | EVA | |
| rs3389546995 | 1200 | C>* | No | EVA | |
| rs3389553991 | 1205 | G>R | No | EVA | |
| rs3389460985 | 1220 | R>W | No | EVA | |
| rs3389554031 | 1232 | P>S | No | EVA | |
| rs3409861464 | 1244 | V>D | No | EVA | |
| rs3408877001 | 1247 | E>G | No | EVA | |
| rs3389531561 | 1254 | N>K | No | EVA | |
| rs3389553328 | 1276 | E>* | No | EVA | |
| rs220099592 | 1310 | T>I | No | EVA | |
| rs3409743806 | 1338 | T>A | No | EVA | |
| rs262766609 | 1339 | G>E | No | EVA | |
| rs262766609 | 1339 | G>V | No | EVA | |
| rs218453078 | 1341 | D>E | No | EVA | |
| rs239011438 | 1341 | D>V | No | EVA | |
| rs254929587 | 1342 | E>G | No | EVA | |
| rs3408430684 | 1349 | P>L | No | EVA | |
| rs3389508948 | 1357 | I>N | No | EVA | |
| rs3389508948 | 1357 | I>S | No | EVA | |
| rs3389553361 | 1387 | Y>C | No | EVA | |
| rs3389568035 | 1388 | V>L | No | EVA | |
| rs3389460955 | 1444 | P>H | No | EVA | |
| rs3408510298 | 1453 | M>L | No | EVA | |
| rs3389508918 | 1461 | I>N | No | EVA | |
| rs3389460907 | 1487 | L>M | No | EVA | |
| rs3389565297 | 1494 | V>I | No | EVA | |
| rs3412971211 | 1496 | H>N | No | EVA | |
| rs3389531580 | 1503 | C>Y | No | EVA | |
| rs3389531523 | 1531 | A>V | No | EVA | |
| rs3409861504 | 1541 | A>V | No | EVA | |
| rs3389554034 | 1580 | E>A | No | EVA | |
| rs3389460996 | 1598 | T>I | No | EVA | |
| rs250192487 | 1634 | E>D | No | EVA | |
| rs3389553305 | 1638 | S>I | No | EVA | |
| rs3389557630 | 1643 | F>L | No | EVA | |
| rs3389553031 | 1662 | Q>R | No | EVA | |
| rs3389519361 | 1687 | N>I | No | EVA | |
| rs3389562736 | 1689 | P>H | No | EVA | |
| rs3389519339 | 1704 | Q>H | No | EVA | |
| rs3409504025 | 1731 | V>E | No | EVA | |
| rs3389546355 | 1737 | L>F | No | EVA | |
| rs3389547975 | 1738 | Q>K | No | EVA |
No associated diseases with Q8CGN4
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| BCOR complex | A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| histone deacetylase binding | Binding to histone deacetylase. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| blastocyst hatching | The hatching of the cellular blastocyst from the zona pellucida. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| histone H2A monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group. |
| negative regulation of bone mineralization | Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. |
| negative regulation of histone H3-K36 methylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. |
| negative regulation of histone H3-K4 methylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. |
| negative regulation of tooth mineralization | Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| odontogenesis | The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
| specification of axis polarity | The pattern specification process in which the polarity of a body or organ axis is established and maintained. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSATPLYGN | VHSWMNSERV | RMCGTSEDRK | IPVNDGDASK | ARLELREETP | LSHSVVDTSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AHRIDGLAAL | SMDRTGLIRE | GLRVPGNIVY | SGLCGLGSEK | GREATPSSLS | GLGFSSERNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EMQFKPNTPE | TVEASAVSGK | PPNGFSAIYK | TPPGIQKSAV | ATAESLGLDR | PASDKQSPLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INGASYLRLP | WVNPYMEGAT | PAIYPFLDSP | NKYSLNMYKA | LLPQQSYGLA | QPLYSPVCTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GERFLYLPPP | HYVNPHIPSS | LASPMRLSTP | SASAAIPPLV | HCSDKSLPWK | MGVNPGNPVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SHSYPHIQNS | KQPRVTSAKA | VNSGLPGDTA | LLLPPSPRPS | ARVHLPTQPA | AETYSEFHKH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YPRISTSPSV | TLTKPYMTAN | SEFSTSRLSN | GKYPKALDGG | DCAQSMPGHT | RKTTVQDRKD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGSPPLLEKQ | TVTKDVTDKP | LDLSSKVVDA | DASKGDHMKK | MAPTVLVHSR | AASGLVLSGS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EIPKETLSPP | GNGCSIYRSE | IISTAPSSWV | VPGPSPNEEN | NGKSLSLKNK | ALDWAIPQQR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSSCPRMGGT | DAVVTNVSGS | VSSSGRPASA | SPAPNANANA | DGTKTSRSSV | DTTPSVIQHV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GQPSSTPAKH | GGSTSSKGAK | ANPEPSFKAS | ENGLPPTSIF | LSPNEAFRSP | AIPYPRSYLP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YAAPEGIALS | PLSLHGKGPV | YPHPVLLPNG | SLFPGHLAPK | PGLPYGLHTS | RPEFVTYQDA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGLGMVHPML | IPHTPIEITK | EEKPERRSRS | HERARYEDPT | LRSRFSEMLE | ASSTKLHPEV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PTDKNLKPNS | SWNQGKTGVK | SDKLVYVDLL | REEADTKTDA | GAPKAGLVAE | NVGQDTEATK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PSADPVIQQR | REFISLREEL | GRITDFHESF | TFKQASSQPV | FSLGKDSGAA | GTNKENLGVQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VATPFLETAL | GSEGPAVTFG | KTQEDPKPFC | VGGAPPNMDV | TPAYTKEGTD | EAESNDGKVL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KPKPSKLAKR | IANSAGYVGD | RFKCVTTELY | ADSSQLSREQ | RALQMEGLQE | DSILCLPAAY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| CERAMMRFSE | LEMKEREGSH | PATKDSEVCK | FSPADWERLK | GNQEKKPKSV | TLEEAIADQN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DSERCEYSTG | NKHDLFEAPE | DKDLPVEKYF | LERPPVSEPP | SDQGVVDTPH | SPTLRLDRKR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KLSGDSTHTE | TAVEELAEDP | LKAKRRRISK | DDWPEREMTN | SSSNHLEDPH | CNELTNLKVC |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| IELTGLHPKK | QRHLLHLRER | WEQQVSAAES | KPGRQSRKEV | AQAVQPEVTS | QGTNITEEKP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GRKKAEAKGN | RGWSEESLKS | CDNEQGLPVL | SGSPPMKSLS | STNASGKKQT | QPSCTPASRL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| PAKQQKIKES | QKTDVLCTGE | DEDCQAASPL | QKYTDNIEKP | SGKRLCKTKH | LIPQESRRSL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| QITGDYYVEN | TDTKMTVRRF | RKRPEPSSDY | DLSPPAKQEP | KPFDRLQQLL | PATQATQLPR |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SNSPQETTQS | RPMPPEARRL | IVNKNAGETL | LQRAARLGYE | EVVLYCLENK | VCDVNHRDNA |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GYCALHEACA | RGWLNIVRHL | LEYGADVNCS | AQDGTRPLHD | AVENDHLEIV | RLLLSYGADP |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| TLATYSGRTI | MKMTHSELME | KFLTDYLNDL | QGRSEDDTSG | AWEFYGSSVC | EPDDESGYDV |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LANPPGPEDP | DEEEDTYSDL | FEFEFAESSL | LPCYNIQVSV | AQGPRNWLLL | SDVLKKLKMS |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| SRIFRSNFPN | LEIVTIAEAE | FYRQVSTSLL | FSCPKDLEAF | NPESKELLDL | VEFTNELQTL |
| 1750 | |||||
| LGSSVEWLHP | SDTGHENYW |