Q8CGA3
Gene name |
Slc43a2 (Lat4) |
Protein name |
Large neutral amino acids transporter small subunit 4 |
Names |
L-type amino acid transporter 4, Solute carrier family 43 member 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:215113 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CGA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CGA3-F1 | Predicted | AlphaFoldDB |
42 variants for Q8CGA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs50219651 | 2 | A>G | No | EVA | |
| rs3389168181 | 4 | T>I | No | EVA | |
| rs3389193711 | 12 | R>S | No | EVA | |
| rs3402610451 | 41 | K>Q | No | EVA | |
| rs26917522 | 59 | S>G | No | EVA | |
| rs241432117 | 64 | S>T | No | EVA | |
| rs217571956 | 72 | L>V | No | EVA | |
| rs3389117864 | 124 | A>G | No | EVA | |
| rs3389168150 | 141 | D>E | No | EVA | |
| rs3389149867 | 152 | A>T | No | EVA | |
| rs1132482350 | 205 | A>T | No | EVA | |
| rs219123398 | 223 | F>L | No | EVA | |
| rs3389179602 | 239 | D>E | No | EVA | |
| rs3389182834 | 244 | V>M | No | EVA | |
| rs3389144257 | 252 | G>C | No | EVA | |
| rs3389182773 | 269 | V>M | No | EVA | |
| rs3389176075 | 275 | V>M | No | EVA | |
| rs3389176120 | 276 | G>S | No | EVA | |
| rs3389183805 | 283 | K>E | No | EVA | |
| rs3389179972 | 292 | H>N | No | EVA | |
| rs3389149939 | 298 | T>N | No | EVA | |
| rs3389176050 | 348 | I>F | No | EVA | |
| rs3389168238 | 356 | D>N | No | EVA | |
| rs3402448935 | 367 | F>C | No | EVA | |
| rs3413123567 | 367 | F>L | No | EVA | |
| rs216261303 | 403 | E>D | No | EVA | |
| rs251572946 | 403 | E>G | No | EVA | |
| rs3389188553 | 407 | G>A | No | EVA | |
| rs3389176051 | 420 | V>I | No | EVA | |
| rs3389182783 | 440 | T>I | No | EVA | |
| rs3389117858 | 444 | P>S | No | EVA | |
| rs3389183808 | 464 | H>R | No | EVA | |
| rs3389183809 | 471 | Y>* | No | EVA | |
| rs3389174147 | 505 | M>L | No | EVA | |
| rs3402508753 | 523 | M>T | No | EVA | |
| rs3389180011 | 524 | S>N | No | EVA | |
| rs3389182779 | 545 | L>P | No | EVA | |
| rs3389182779 | 545 | L>R | No | EVA | |
| rs3389174090 | 551 | D>N | No | EVA | |
| rs213015437 | 564 | R>Q | No | EVA | |
| rs3389174123 | 565 | E>G | No | EVA | |
| rs3389188570 | 566 | A>T | No | EVA |
No associated diseases with Q8CGA3
No regional properties for Q8CGA3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8CGA3 | |||
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-amino acid transmembrane transporter activity | Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. |
| neutral amino acid transmembrane transporter activity | Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| L-amino acid transport | The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of amino acid transport | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of leucine import | Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. |
| neutral amino acid transport | The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NBI5 | SLC43A3 | Equilibrative nucleobase transporter 1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPTLATAHR | RRWWMACTAV | LENLLFSAVL | LGWGSLLIML | KSEGFYSYLC | TKPENVTNST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGGSAEPEPE | ELSLVNGWLS | CKAQDEILNL | AFTVGSFLLS | AITLPLGIIM | DKYGPRKLRL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGSACFAVSC | LLIAYGASNP | DSLSVLIFIA | LALNGFGGMC | MTFTSLTLPN | MFGDLRSTFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALMIGSYASS | AVTFPGIKLI | YDAGASFIGI | LVVWAGCSGL | VFFNCFFNWP | LEPFPGPEDM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DYSVKIKFSW | LGFDHKITGK | QFYKQVTTVG | RRLSVGSSMR | TAKEQAALQE | GHKLCLSTVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEVKCQPDAA | AAPSFMHSVF | SPLLVLSLVT | MCVTQLRLIF | YMGAMNSILE | FLVRGDQKTV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALYTSIFGAL | QLLCLLTAPV | IGYIMDWKLK | ECEDTSEEPE | EKEGTQGEKK | QKRDRQIQKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TNAMRAFAFT | NVLLVGFGVT | CLIPNLPLQI | FSFVLHTIVR | GFIHSAVGGL | YAAVYPSTQF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GSLTGLQSLV | SALFALLQQP | LYLAMMGPLG | GDPLWVNVGL | LAMSMLGFCL | PLYLICYRRQ |
| 550 | 560 | ||||
| LERQLQQKRE | DSKLFLKING | SSNREAFV |