Q8CEC5
Gene name |
Nkiras1 |
Protein name |
NF-kappa-B inhibitor-interacting Ras-like protein 1 |
Names |
I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1, KappaB-Ras1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69721 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CEC5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CEC5-F1 | Predicted | AlphaFoldDB |
9 variants for Q8CEC5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389304333 | 5 | C>Y | No | EVA | |
| rs3389277776 | 36 | C>Y | No | EVA | |
| rs3389277743 | 87 | S>T | No | EVA | |
| rs3389300867 | 94 | F>L | No | EVA | |
| rs3389262349 | 95 | Q>R | No | EVA | |
| rs3389270987 | 116 | V>D | No | EVA | |
| rs3389305401 | 168 | L>I | No | EVA | |
| rs3389262418 | 176 | S>R | No | EVA | |
| rs3389305413 | 183 | K>R | No | EVA |
No associated diseases with Q8CEC5
1 regional properties for Q8CEC5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 3 - 157 | IPR005225 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activating protein binding | Binding to a GTPase activating protein. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| lung alveolus development | The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. |
| Ral protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state. |
| regulation of tumor necrosis factor-mediated signaling pathway | Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. |
| surfactant homeostasis | Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKGCKVVIC | GLLSVGKTAI | LEQLLYGNHT | IGMEDCETLE | DVYMASVETD | RGVKEQLHLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTRGLQKGVE | LPKHYFSFAD | GFVLVYSVNN | LESFQRVELL | KKEIDKFKDK | KEVAIVVLGN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLDLSEQRQV | DADVAQQWAR | SEKVKLWEVT | VTDRRTLIEP | FTLLASKLSQ | PQSKSSFPLP |
| 190 | |||||
| GRKNKGNSNP | EN |