Q8CC12
PR
Gene name |
Cdan1 |
Protein name |
Codanin-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68968 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CC12
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CC12-F1 | Predicted | AlphaFoldDB |
34 variants for Q8CC12
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs228794258 | 76 | V>G | No | EVA | |
| rs254961936 | 105 | P>S | No | EVA | |
| rs46070787 | 140 | A>P | No | EVA | |
| rs3388572917 | 199 | S>Y | No | EVA | |
| rs3388583944 | 277 | I>F | No | EVA | |
| rs3388582751 | 602 | E>D | No | EVA | |
| rs3388586999 | 641 | L>W | No | EVA | |
| rs3392143516 | 687 | Q>R | No | EVA | |
| rs3413038619 | 720 | S>N | No | EVA | |
| rs251265948 | 727 | R>H | No | EVA | |
| rs3388586985 | 732 | L>S | No | EVA | |
| rs3388579768 | 774 | Q>E | No | EVA | |
| rs3388584265 | 775 | V>* | No | EVA | |
| rs3388584276 | 777 | A>V | No | EVA | |
| rs3388577996 | 779 | E>V | No | EVA | |
| rs3388577977 | 790 | D>G | No | EVA | |
| rs3392143503 | 817 | W>* | No | EVA | |
| rs265503419 | 914 | G>E | No | EVA | |
| rs3388583553 | 958 | T>S | No | EVA | |
| rs3388586333 | 965 | S>T | No | EVA | |
| rs3388582766 | 970 | A>V | No | EVA | |
| rs3388580339 | 985 | N>T | No | EVA | |
| rs3388582760 | 1004 | A>V | No | EVA | |
| rs3388580354 | 1013 | V>G | No | EVA | |
| rs3392096983 | 1044 | Q>* | No | EVA | |
| rs3388579778 | 1057 | E>D | No | EVA | |
| rs3388583904 | 1120 | G>R | No | EVA | |
| rs3392171948 | 1144 | Q>* | No | EVA | |
| rs3388587043 | 1177 | D>* | No | EVA | |
| rs3388584244 | 1177 | D>G* | No | EVA | |
| rs3388572916 | 1180 | G>* | No | EVA | |
| rs3388583533 | 1213 | A>V | No | EVA | |
| rs3388584266 | 1226 | E>D | No | EVA | |
| rs3388584260 | 1235 | V>I | No | EVA |
No associated diseases with Q8CC12
1 regional properties for Q8CC12
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Codanin-1, C-terminal domain | 790 - 904 | IPR028171 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| negative regulation of DNA replication | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
| nuclear envelope organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAVLESLLR | EEVPVAAAVR | WIARSTPSSE | DSSEVAALSA | LRPLRKEFVP | FLLNFLREQS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRVLPQGPST | PAKTPVASAA | LPARQGAPAR | GGRGARSQLF | PAAEPLSAAA | EAPLARRAGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRGPGPGPSR | ERGGRGSGAA | EEGASGESPP | WAGGRKPKGS | GSPGSPRLSL | SDPPNLSNLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EFPPVGTVPP | GSAGRTKPSR | RINPTPVSEE | RSLSKPKTCF | TSPPISCVPS | SQPSTLDTSP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WGLGLPPGCR | SLQEEREMLR | KARTKQLQQS | PTPASPIPES | GSPVPSRTGN | LTAEPADPAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSSRQRLELV | ALIYSSCIAE | NLVPNLFLEL | FFVLQLLTAR | RMVATKDSDL | ESSQGALDSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DTPLFRSIHD | CVFFAVQVLE | HQFQVLSYLD | KGTLKLLAEN | ERLLCFSPAL | QGRLRAAYEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVAKVSLVIP | PSAQAVSFQP | ETDNRANFSS | DRAFHTFKKQ | RDVFYEVLRE | WEDHHEEPSW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DFEKGLGSRI | RAMMGQLSAA | CSHSHFVRLF | QKQLLQMCQS | PGGAGGSVLG | EAPDVLNMLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ADKLGRLRQL | QERLIAPQSS | GGPCPPPTFP | GCQGFFRDFI | MSASSFHFNQ | HLMDSLSLKI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RELNGLRLPQ | HEPGDEDGES | DMDWQGERRQ | FAVVLLSLRL | LAKFLGFVAF | LPYRGHEPPP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TRELQDSILA | LRSQVPPVLD | IRALLQQGLW | ARRAVLTVPW | LVEFLSFADH | IVPLLDYYRS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VFTLLLRLHR | SLVLSKENEG | EMCFLNKLLL | LAVLGWLFQI | PTVPEDLFFL | EDGQVDAFEV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TTTASEHGLD | SVPVVDQQLL | YTCCPYIGEL | RKLLASWVSG | SSGRSGGFVR | KITPTTTSSL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GALPLQTSQG | LQAQLAEAFF | HNQPPSLRRT | VEFVAERIGS | NCVKHIKATL | VADLVHQAES |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LLQEQLVARG | QEGGDPAQLL | ESLCSQLCPH | GAQALTQGRE | FCQRKSPTAV | RALLPEETPA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AVLSSAENIA | VGLATEKACS | WLSANITALI | RREVKAAVSR | MLRAQGPEPT | ARVERRGCSR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ACEHHAPLPS | HLISEIKFHH | CSLQDVLSLA | AGPRDPEEGV | SPEHLEQLLN | QMGQSLRCRQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FLCPTAEQHL | AKCSVELASL | LVADQIPILG | PPTQHRLERG | HARRLLHMLL | SLWKDDFQGP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VPLQLLLSPR | NVGLLADTRP | REWDLLLFLL | RELVEKDLMG | HLEIEACLGR | LNEAQWPGDF |
| 1210 | 1220 | 1230 | |||
| SEELSTLFRL | FLAEPHLLEP | QLRACELMQP | NRGTVLAQS |