AiPD: Autoinhibited Protein Database

Gene name	Gramd4
Protein name	GRAM domain-containing protein 4
Names	Death-inducing protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:223752
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

41-117 (Predicted disordered autoinhibitory region) PR

41-117 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CB44-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs234160199	20	S>F	No	EVA
rs3389395244	41	V>I	No	EVA
rs3389360553	46	R>S	No	EVA
rs3405501417	51	N>D	No	EVA
rs3406472046	61	F>W	No	EVA
rs236894582	69	L>F	No	EVA
rs3406354176	76	P>S	No	EVA
rs3389299090	90	K>E	No	EVA
rs3389375112	92	P>L	No	EVA
rs3389360530	110	T>N	No	EVA
rs3389389180	156	T>I	No	EVA
rs3389389167	163	Q>H	No	EVA
rs3389332229	173	I>T	No	EVA
rs3389395220	187	S>P	No	EVA
rs230045118	194	P>S	No	EVA
rs3389299141	207	G>C	No	EVA
rs3389384506	227	E>*	No	EVA
rs3406493996	249	E>A	No	EVA
rs3389389191	409	Y>*	No	EVA
rs3389343528	448	W>C	No	EVA
rs3406098689	463	A>D	No	EVA
rs3389380999	524	C>F	No	EVA
rs3389373624	538	I>M	No	EVA
rs3389395219	547	E>G	No	EVA
rs3406568408	600	P>A	No	EVA
rs3406410525	600	P>R	No	EVA

Type	Name	Position	InterPro Accession
domain	GRAM domain	500 - 621	IPR004182
domain	GRAMDC4, PH-GRAM domain	515 - 620	IPR037845

		Description
EC Number
Subcellular Localization	Mitochondrion membrane ; Multi-pass membrane protein Endoplasmic reticulum membrane ; Multi-pass membrane protein	Colocalizes with COX4I1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
No GO annotations for molecular function

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
negative regulation of toll-like receptor 9 signaling pathway	Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins